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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to CXCR4
CXCR4 — GNAI1
Pathways - manually collected, often from reviews:
BioCarta cxcr4 signaling pathway :
G-alpha-i/G-beta/G-gamma complex (GNAI1-GNGT1-GNB1)
→
SDF-1/CXCR4/g-alpha-q complex (CXCL12-CXCR4-GNAQ)
(modification, collaborate)
BioCarta cxcr4 signaling pathway :
SDF-1/CXCR4/g-alpha-q complex (CXCL12-CXCR4-GNAQ)
→
G-alpha-I (GNAI1)
(modification, activates)
KEGG Axon guidance :
CXCR4
→
GNAI1/GNAI2/GNAI3
(protein-protein, activation)
KEGG Axon guidance :
CXCR4
→
GNAI1/GNAI2/GNAI3
(protein-protein, activation)
KEGG Leukocyte transendothelial migration :
CXCR4
→
GNAI1/GNAI2/GNAI3
(protein-protein, binding/association)
KEGG Chemokine signaling pathway :
CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1
→
GNAI1/GNAI2/GNAI3
(protein-protein, activation)
NCI Pathway Database CXCR4-mediated signaling events :
SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2)
→
Gi family/GTP/RGS1 complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-RGS1)
(modification, activates)
Wang et al., Blood 2000 , Zhang et al., Blood 2001 , Okabe et al., J Hematother Stem Cell Res 2002 , Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database CXCR4-mediated signaling events :
SDF1/CXCR4 complex (CXCL12-CXCR4)
→
Gi family/GTP complex (GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1)
(modification, activates)
Tan et al., J Biol Chem 2006
Evidence: mutant phenotype
Reactome Reaction :
GNAI1
→
CXCR4
(reaction)
Lambert et al., Science signaling 2008 , Lerea et al., Neuron 1989 , Van Dop et al., Nucleic Acids Res 1989 , Itoh et al., J Biol Chem 1988 , Takami et al., Brain Res Mol Brain Res 1994
Reactome Reaction :
GNAI1
→
CXCR4
(indirect_complex)
Lerea et al., Neuron 1989 , Van Dop et al., Nucleic Acids Res 1989 , Itoh et al., J Biol Chem 1988 , Takami et al., Brain Res Mol Brain Res 1994
WikiPathways Chemokine signaling pathway :
CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6
→
GNAI1/GNAI2/GNAI3
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *