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GJA1 — PRKAR2A

Text-mined interactions from Literome

Ogawa et al., Mol Reprod Dev 2000 : Dibutyryl cAMP ( dbcAMP ), a protein kinase A (PKA) activator, added to the culture medium increased the phosphorylation of Cx43 and Cx43 positive spots
Cherian et al., J Biol Chem 2003 : The adenylate cyclase activators, forskolin and 8-bromo-cAMP, enhanced intercellular connectivity, the number of functional gap junctions, and Cx43 protein expression, whereas the PKA inhibitor, H89, inhibited the stimulatory effect of PGE2 on gap junctions
Kalma et al., Endocrinology 2004 : We show herein that LH inhibits Cx43 expression by reducing its rate of translation and that this effect is mediated by both PKA and MAPK
Somekawa et al., Circ Res 2005 : Here we demonstrated that the gating function of GJ is enhanced by the protein kinase A (PKA) dependent signal, and that the accumulation of connexin43 (Cx43) , the most abundant Cx in myocytes, is enhanced by an exchange protein directly activated by cAMP ( Epac ) ( Rap1 activator ) -dependent signal
Luo et al., J Gene Med 2007 (Carcinoma) : The PKA and PI3K signal transduction pathways are likely involved in enhanced Cx43 expression as inhibitors of these pathways prevented Cx43 upregulation
Mayama et al., Experimental and clinical cardiology 2007 : At the beginning of fibrillation, an increase in the cardiac tissue AII level, an augmentation of the protein kinase C (PKC)-epsilon activity, the presence of PKC mediated hyperphosphorylation, a suppression of the PKA mediated phosphorylation of Cx43 and a reduction in the expression of Cx43 at the gap junction were observed
Matsumura et al., Experimental and clinical cardiology 2006 : The effects of hypoxia, intracellular Ca ( 2+ ) overload and intracellular acidosis on the PKA mediated phosphorylation of connexin 43 (Cx43) were examined in relation to the function of the cardiac gap junction ... Cyclic AMP or the activation of PKA promotes the intercellular electrical coupling that accompanies an augmentation of the PKA mediated phosphorylation of Cx43 ... Electrical cell-to-cell decoupling and reduction of the PKA mediated phosphorylation of Cx43 were dependent on the progression of hypoxia ... In cardiac ventricular muscle cells, cyclic AMP or the activation of PKA promotes electrical cell-to-cell coupling through the gap junction due to an augmentation of the PKA mediated phosphorylation of Cx43 in the early stage of hypoxia, as well as in normoxia ... The suppression of PKA mediated phosphorylation of Cx43 during hypoxia may be caused by an increase in the intracellular ionic strength of Ca ( 2+ ) and H ( + )
Imanaga et al., Experimental and clinical cardiology 2004 : Activation of PKA promotes cell-to-cell coupling due to augmentation of the PKA mediated phosphorylation of Cx43 , with a rise in the quantity of and an increase in the expression of Cx43 ... A rise in the ionic strength of Ca ( 2+ ) and H ( + ) impaired cell communication, with the inhibition of PKA mediated Cx43 phosphorylation
Duquesnes et al., Pflugers Arch 2010 : Interestingly, inhibition of PKA partly suppressed both Iso induced increases in Cx43 phosphorylation and in GJIC
Joshi et al., Frontiers in physiology 2012 : Interestingly, stimulation of Cx43 expression by DADS was not dependent on PKA , PKG or PKC