Gene interactions and pathways from curated databases and text-mining

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CASP5 — GJA1

Text-mined interactions from Literome

Lin et al., Curr Eye Res 2007 (Diabetes Mellitus, Experimental) : PKC-gamma activation was measured by enzyme activity assay and by Western blotting to show autophosphorylation on Thr514. Cellular insulin-like growth factor-1 (IGF-1), PKC-gamma phosphorylation of Cx43 on Ser368, and activation of phospholipase C-gamma 1 ( PLC-gamma 1 ), extracellular signal regulated kinase ( ERK1/2 ), and caspase-3 were determined by Western blotting
Sabarinathan et al., Mol Cell Biochem 2010 (Glioma...) : These findings provide evidence that NGEN 's apoptotic effect, modulation of Bcl-2/Bax ratio leads to release of Cyt C from mitochondria, thereby activation of caspase-3 and caspase-9 is mediated by enhanced expression of Cx43