Gene interactions and pathways from curated databases and text-mining

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GHR — MAPK6

Text-mined interactions from Literome

Liang et al., Endocrinology 1999 : GH induces activation of the GH receptor (GHR) associated cytoplasmic tyrosine kinase, JAK2, resulting in tyrosine phosphorylation of the GHR and activation of STAT ( signal transducer and activator of transcription ), Ras-mitogen activated protein kinase , and phosphoinositol 3-kinase signaling pathways, among others
Winston et al., J Biol Chem 1995 : Employing the transient expression of dominant negative forms of H-Ras and Raf-1, we determined that the GHR/JAK2 mediated activation of ERK2/MAPK is dependent on both Ras and Raf