Gene interactions and pathways from curated databases and text-mining

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GDNF — MAPK6

Text-mined interactions from Literome

Nicole et al., J Neurosci 2001 (Brain Ischemia...) : Together, these results describe a novel mechanism by which the activation of MAPK induced by GDNF modulates NMDA receptor activity, a mechanism that could be responsible for the neuroprotective effect of GDNF in acute brain injury
Hisaoka et al., J Neurochem 2001 (Glioblastoma) : These results suggested that amitriptyline induced GDNF synthesis and release occurred at the transcriptional level, and may be regulated by MEK/MAPK signalling
Wiklund et al., J Neurosci Res 2002 (MAP Kinase Signaling System) : Other findings indicate that GDNF exerts its growth effects by activation of MAPK and that expression of the conditioning effect in vitro in preaxotomized preparations also requires activation of MAPK
Steinkamp et al., Gastroenterology 2003 : GDNF induced activation of Akt ( protein kinase B [PKB ] ) and mitogen activated protein kinase ( MAPK ) in the colonic epithelial cell lines HT-29 and SW480 was studied ... GDNF potently activated MAPK and Akt ( PKB ) in colonic epithelial cells
Sawai et al., Cancer Res 2005 (Adenocarcinoma...) : The modifying effect of G691S RET on GDNF induced invasion and mitogen activated protein kinase ( MAPK ) signaling was evaluated
Sooranna et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : All three stimuli increased PGHS-2 and IL-8 mRNA expression in a MAPK dependent manner, but while the MAPK inhibitors reduced the IL-1beta induced activation of activating transcription factor (ATF)-2 , liver activating protein (LAP) and c-jun, the stretch induced increase in LAP was unaffected by MAPK-inhibition and only JNK inhibition appeared to reduce c-jun activation
Koeberle et al., Cell Death Differ 2008 : However, GDNF also required Src and mitogen activated protein kinase activity to prevent RGC apoptosis
Ledda et al., J Neurosci 2008 : In particular, we demonstrate that Lrig1 is capable of physically interacting with Ret and that Lrig1/Ret association inhibits GDNF binding, recruitment of Ret to lipid rafts, receptor autophosphorylation, and mitogen activated protein kinase ( MAPK ) activation in response to GDNF ... Downregulation of Lrig1 using small interference RNA knock-down experiments potentiates both neuronal differentiation and MAPK activation in response to GDNF
Battaglia et al., PloS one 2009 : In pure cultures of striatal neurons, the increase in GDNF induced by LY379268 required the activation of the mitogen activated protein kinase and phosphatidylinositol-3-kinase pathways, as shown by the use of specific inhibitors of the two pathways
Chatterjee et al., Hum Genet 2012 (Vesico-Ureteral Reflux) : A family with duplicated collecting system had a novel mutation, RET-R831Q, which showed markedly decreased GDNF dependent MAPK activity