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CREB1 — GDNF
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
GDNF
—
CREB1
(interaction, mapped from grid reactome intact)
-
STRING interaction:
GDNF
—
CREB1
(interaction, mapped from grid reactome intact)
-
STRING interaction:
CREB1
—
GDNF
(interaction, mapped from grid kegg_pathways intact)
-
STRING interaction:
CREB1
—
GDNF
(interaction, mapped from grid kegg_pathways intact)
Text-mined interactions from Literome
Pezeshki et al., J Neurosci Res 2001
:
Stimulation of B104 and Mes42 cells with
GDNF , but not with NTN, for 10 min
resulted in
CREB phosphorylation ... In apparent contrast, neither NTN nor
GDNF promoted
CREB activation in LS and Neuro2A cells
Simi et al., J Neurochem 2005
:
We found that ( 1 ) LPS induced c-fos mRNA levels were sensitive to p38 mitogen activated protein kinase ( MAPK ) inhibitors but not to mitogen-activated/extracellular signal regulated kinase ( ERK ) or calcium-calmodulin dependent kinase inhibitors, ( 2 ) LPS activated both serum response element ( SRE ) and cyclic AMP/calcium response element ( CRE ) -driven luciferase reporters in transient transfection assays, ( 3 ) LPS induced the phosphorylation of Elk1 CRE binding protein ( CREB )
/activated transcription factor-1 (ATF-1) and the
activation of GAL4-Elk1 and
GAL4-CREB chimeric proteins, and ( 4 ) mutation of both SRE and CRE elements was necessary and sufficient to completely abolish LPS induction of a rat c-fos proximal promoter-luciferase reporter
Cen et al., J Neurosci 2006
:
These findings show that
CREB plays a key role in transcriptional regulation of
GDNF expression induced by Leu-Ile
He et al., Stem Cells 2008
:
GDNF stimulated the phosphorylation of
CREB-1 , ATF-1, and CREM-1, and c-fos transcription ... Together, these data suggest that
GDNF induces
CREB/ATF-1 family member phosphorylation and c-fos transcription via the Ras/ERK1/2 pathway to promote the proliferation of SSC
Samten et al., J Immunol 2008
:
Additionally,
ATF-2 controls expression of
CREB and c-Jun during T cell activation
Versteeg et al., Journal of thrombosis and haemostasis : JTH 2008
:
Factor VIIa led to
a TF-dependent , but TF cytoplasmic domain independent phosphorylation and
activation of
CREB in BHK TF, HaCaT and HUVEC
Yan et al., Neurochem Int 2011
:
Thus, through a2A adrenergic receptors, DEX may activate astrocytes, and promote
GDNF release to protect neurons after stroke, and this signaling is possibly
dependent on PKCa and
CREB activation