Gene interactions and pathways from curated databases and text-mining

◀ Back to CREB1

CREB1 — GDNF

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

  • STRING interaction: GDNF — CREB1 (interaction, mapped from grid reactome intact)
  • STRING interaction: GDNF — CREB1 (interaction, mapped from grid reactome intact)
  • STRING interaction: CREB1 — GDNF (interaction, mapped from grid kegg_pathways intact)
  • STRING interaction: CREB1 — GDNF (interaction, mapped from grid kegg_pathways intact)

Text-mined interactions from Literome

Pezeshki et al., J Neurosci Res 2001 : Stimulation of B104 and Mes42 cells with GDNF , but not with NTN, for 10 min resulted in CREB phosphorylation ... In apparent contrast, neither NTN nor GDNF promoted CREB activation in LS and Neuro2A cells
Simi et al., J Neurochem 2005 : We found that ( 1 ) LPS induced c-fos mRNA levels were sensitive to p38 mitogen activated protein kinase ( MAPK ) inhibitors but not to mitogen-activated/extracellular signal regulated kinase ( ERK ) or calcium-calmodulin dependent kinase inhibitors, ( 2 ) LPS activated both serum response element ( SRE ) and cyclic AMP/calcium response element ( CRE ) -driven luciferase reporters in transient transfection assays, ( 3 ) LPS induced the phosphorylation of Elk1 CRE binding protein ( CREB ) /activated transcription factor-1 (ATF-1) and the activation of GAL4-Elk1 and GAL4-CREB chimeric proteins, and ( 4 ) mutation of both SRE and CRE elements was necessary and sufficient to completely abolish LPS induction of a rat c-fos proximal promoter-luciferase reporter
Cen et al., J Neurosci 2006 : These findings show that CREB plays a key role in transcriptional regulation of GDNF expression induced by Leu-Ile
He et al., Stem Cells 2008 : GDNF stimulated the phosphorylation of CREB-1 , ATF-1, and CREM-1, and c-fos transcription ... Together, these data suggest that GDNF induces CREB/ATF-1 family member phosphorylation and c-fos transcription via the Ras/ERK1/2 pathway to promote the proliferation of SSC
Samten et al., J Immunol 2008 : Additionally, ATF-2 controls expression of CREB and c-Jun during T cell activation
Versteeg et al., Journal of thrombosis and haemostasis : JTH 2008 : Factor VIIa led to a TF-dependent , but TF cytoplasmic domain independent phosphorylation and activation of CREB in BHK TF, HaCaT and HUVEC
Yan et al., Neurochem Int 2011 : Thus, through a2A adrenergic receptors, DEX may activate astrocytes, and promote GDNF release to protect neurons after stroke, and this signaling is possibly dependent on PKCa and CREB activation