Gene interactions and pathways from curated databases and text-mining

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GCG — PRKAR2A

Text-mined interactions from Literome

Alemán et al., Am J Physiol Endocrinol Metab 2005 (Hepatoblastoma) : However, glucagon can activate the following two possible transduction pathways : protein kinase A (PKA) and protein kinase C ( PKC )
Brubaker et al., Adv Exp Med Biol 1991 : Pancreatic glucagon secretion in response to PKA is subject to further modulation by prevailing glucose concentrations
Baum et al., Am J Physiol Endocrinol Metab 2009 : Glucagon alone had no effect on mTORC1 signaling but stimulated the activity of protein kinase A (PKA)
Mao et al., Proc Natl Acad Sci U S A 2011 (Obesity) : Glucagon stimulated protein kinase PKA , which in turn phosphorylated IRE1a at Ser ( 724 ), a highly conserved site within the kinase activation domain
Ye et al., Am J Physiol Heart Circ Physiol 2013 (Diabetes Mellitus, Type 2...) : Glucagon-like peptide (GLP)-1 receptor activation increases intracellular cAMP with downstream activation of PKA
Mighiu et al., Nat Med 2013 : Glucagon activates hepatic protein kinase A (PKA) to increase glucose production, but the gluco-stimulatory effect is transient even in the presence of continuous intravenous glucagon infusion