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GCG — PRKAR2A
Text-mined interactions from Literome
Alemán et al., Am J Physiol Endocrinol Metab 2005
(Hepatoblastoma) :
However,
glucagon can
activate the following two possible transduction pathways :
protein kinase A (PKA) and protein kinase C ( PKC )
Brubaker et al., Adv Exp Med Biol 1991
:
Pancreatic
glucagon secretion in
response to
PKA is subject to further modulation by prevailing glucose concentrations
Baum et al., Am J Physiol Endocrinol Metab 2009
:
Glucagon alone had no effect on mTORC1 signaling but
stimulated the activity of
protein kinase A (PKA)
Mao et al., Proc Natl Acad Sci U S A 2011
(Obesity) :
Glucagon stimulated protein kinase
PKA , which in turn phosphorylated IRE1a at Ser ( 724 ), a highly conserved site within the kinase activation domain
Ye et al., Am J Physiol Heart Circ Physiol 2013
(Diabetes Mellitus, Type 2...) :
Glucagon-like peptide (GLP)-1 receptor activation
increases intracellular cAMP with downstream activation of
PKA
Mighiu et al., Nat Med 2013
:
Glucagon activates hepatic
protein kinase A (PKA) to increase glucose production, but the gluco-stimulatory effect is transient even in the presence of continuous intravenous glucagon infusion