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GATA4 — MAPK3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kitta et al., Biochem J 2001
:
In contrast, the activation of
MAPK by phenylephrine or H ( 2 ) O ( 2 ) was weak and did not
lead to
GATA-4 phosphorylation
Liang et al., Mol Cell Biol 2001
(MAP Kinase Signaling System) :
The transcription factor
GATA4 is
activated by
extracellular signal regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes
Tremblay et al., J Biol Chem 2003
:
We now show that the rapid phosphorylation of
GATA-4 induced by cAMP in vivo can be
blocked by a PKA-specific inhibitor but not by
mitogen activated protein kinase inhibitors, indicating that GATA-4 is predominantly phosphorylated by PKA in response to cAMP in gonadal cells
Liu et al., J Cell Sci 2009
:
Pharmacological inhibition of ERK1/2 or p38
MAPK blocked vitronectin induced
GATA4 nuclear translocation and endoderm maturation, whereas expression of a constitutively active ERK kinase ( MEK1 ) or p38 MAPK in the mutant cells rescued endoderm maturation in integrin-beta1-null endoderm cells
Gierl et al., Dev Cell 2012
(Gonadal Dysgenesis, 46,XY...) :
Moreover, the transcription factor
GATA4 , which is required for Sry expression, binds to the Sry promoter in vivo in a
MAPK dependent manner