Gene interactions and pathways from curated databases and text-mining

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GAB2 — MAPK3

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2001 : Overexpression of Gab2 in FD-Fms cells enhanced both mitogen activated protein kinase ( MAPK ) activity and macrophage differentiation, but reduced proliferation, in response to M-CSF
Million et al., Mol Cell Biol 2004 (Cell Transformation, Neoplastic...) : A Tel-Abl point mutant ( Y314F ) and a splice variant without TEL exon 5 sequences ( Deltae5 ) lacked Grb2 interaction and exhibited decreased binding and phosphorylation of the scaffolding protein Gab2 and impaired activation of phosphatidylinositol 3-kinase, Akt, and extracellular signal regulated kinase/mitogen activated protein kinase in hematopoietic cells
Zhang et al., Mol Cell Biol 2013 (Breast Neoplasms) : We now demonstrate that activation of the Ras/mitogen activated protein kinase ( MAPK ) pathway promotes Gab2 phosphorylation on basic consensus motifs