Gene interactions and pathways from curated databases and text-mining

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FSHR — IGF1

Text-mined interactions from Literome

Minegishi et al., Biol Reprod 2000 : A role of insulin-like growth factor I for follicle stimulating hormone receptor expression in rat granulosa cells ... The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor I (IGF-I) on FSH receptor (FSHR) in rat granulosa cells ... We then investigated whether the effect of IGF-I and FSH on FSHR mRNA levels was the result of increased transcription and/or altered mRNA stability ... These data suggest a possible role for changes in FSHR mRNA stability in the IGF-I induced regulation of FSHR in rat granulosa cells ... Our data suggest that the IGF-I effect on FSHR expression is related to cAMP production induced by FSH and may maintain FSHR mRNA level because of prolonged FSHR mRNA stability
Spicer et al., Anim Reprod Sci 2011 : RT-PCR measuring abundance of side-chain cleavage enzyme ( CYP11A1 ), aromatase ( CYP19A1 ), FSH receptor (FSHR) and LH receptor ( LHCGR ) mRNA in large- and small-follicle granulosa cells indicated that resistin reduced the stimulatory effect of IGF-I on CPY11A1 mRNA abundance in large-follicle granulosa cells but had no effect on CYP19A1, FSHR or LHCGR mRNA abundance in large- or small-follicle granulosa cells
Brito et al., Res Vet Sci 2012 : The interaction between IGF-1 and FSH increased the mRNA levels of IGF-1 and FSHR , and FSH increased the expression of the IGFR-1 mRNA
Zhou et al., Mol Endocrinol 1997 : To test the alternative hypothesis that IGF-I regulates FSHR gene expression, we studied ovaries from IGF-I knockout mice