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FSHR — IGF1
Text-mined interactions from Literome
Minegishi et al., Biol Reprod 2000
:
A
role of
insulin-like growth factor I for
follicle stimulating hormone receptor expression in rat granulosa cells ... The present study was undertaken to identify the mechanisms underlying the
effect of
insulin-like growth factor I (IGF-I) on
FSH receptor (FSHR) in rat granulosa cells ... We then investigated whether the
effect of
IGF-I and FSH on
FSHR mRNA levels was the result of increased transcription and/or altered mRNA stability ... These data suggest a possible role for changes in FSHR mRNA stability in the
IGF-I induced regulation of
FSHR in rat granulosa cells ... Our data suggest that the
IGF-I effect on
FSHR expression is related to cAMP production induced by FSH and may maintain FSHR mRNA level because of prolonged FSHR mRNA stability
Spicer et al., Anim Reprod Sci 2011
:
RT-PCR measuring abundance of side-chain cleavage enzyme ( CYP11A1 ), aromatase ( CYP19A1 ), FSH receptor (FSHR) and LH receptor ( LHCGR ) mRNA in large- and small-follicle granulosa cells indicated that resistin reduced the stimulatory
effect of
IGF-I on CPY11A1 mRNA abundance in large-follicle granulosa cells but had no effect on CYP19A1,
FSHR or LHCGR mRNA abundance in large- or small-follicle granulosa cells
Brito et al., Res Vet Sci 2012
:
The interaction between
IGF-1 and FSH
increased the mRNA levels of IGF-1 and
FSHR , and FSH increased the expression of the IGFR-1 mRNA
Zhou et al., Mol Endocrinol 1997
:
To test the alternative hypothesis that
IGF-I regulates
FSHR gene expression, we studied ovaries from IGF-I knockout mice