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FRS2 — MAPK3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database FGF signaling pathway:
Erk1-2-active (MAPK3/MAPK1)
→
FGFR/FGF/Syndecan-2/FRS2 complex (SDC2-FRS2)
(modification, activates)
Lax et al., Mol Cell 2002
Evidence: mutant phenotype, other species
-
Reactome Reaction:
MAPK3
→
FRS2
(reaction)
Lax et al., Mol Cell 2002, Wu et al., Biol Chem 2003, Gotoh et al., Cancer Sci 2008, Zhou et al., Cell Res 2009
Text-mined interactions from Literome
Kornmann et al., Gastroenterology 2002
(Cell Transformation, Neoplastic...) :
In vitro, TAKA-1 cells stably transfected with FGFR-1 IIIc exhibited increased basal growth ; enhanced basal tyrosine phosphorylation of
FGFR substrate-2 (FRS2) , Shc, and phospholipase Cgamma ; and increased
activation of mitogen activated protein kinase (
MAPK )
Wu et al., Biol Chem 2003
:
Upon EGF stimulation,
FRS2 mediates enhanced
MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues ... Upon EGF stimulation,
FRS2 mediates enhanced
MAPK activity and undergoes phosphorylation on tyrosine as well as serine/threonine residues
Yokote et al., Proc Natl Acad Sci U S A 2005
:
Moreover, both receptors stimulate tyrosine phosphorylation of the docking protein
FRS2alpha and
induce mitogen activated protein kinase stimulation with a time course and intensity that depends on the ligand that is applied
Easton et al., J Neurochem 2006
(Neuroblastoma) :
In addition to Shc, fibroblast growth
factor receptor substrate 2 (FRS2) is
required for the BDNF induced activation of
MAPK
Finetti et al., Circ Res 2009
(Corneal Neovascularization) :
Using Western blotting assay, we demonstrated that PGE ( 2 ) induced upregulation of components of the FGF-2 pathway : FGF-2 protein, phosphorylation of FGF receptor type 1 (FGFR1),
activation of
FRS2alpha ( FGFR substrate 2alpha ), phospholipase Cgamma, endothelial nitric oxide synthase,
extracellular signal regulated kinase 1/2 , and the transcription factor STAT-3