Gene interactions and pathways from curated databases and text-mining

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CXCR4 — FPR1

Pathways - manually collected, often from reviews:

  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
  • BioCarta chrebp regulation by carbohydrates and camp: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) (modification, collaborate)
  • BioCarta activation of camp-dependent protein kinase pka: G-protein receptor/G-gamma/G-beta/G-alpha-S/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-GNAS) → G-protein receptor/G-gamma/G-beta/Ligand complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNGT1-GNB1-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3) (modification, collaborate)
  • BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → GPCR/g-alpha-s/g-beta/g-gamma/GDP complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-GNAS-GNGT1-GNB1) (modification, collaborate)
  • BioCarta role of ß-arrestins in the activation and targeting of map kinases: Ligand/GPCR/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) → Ligand/GPCR(+)/g-beta/g-gamma complex (HTR2C_ADRA1B_AGTR2_CHRM1_CCR5_PTGER1_P2RY2_CCR3_CXCR4_FPR1_ADRB2-CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-GNGT1-GNB1) (modification, collaborate)
  • Reactome Reaction: FPR1 → CXCR4 (reaction) Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994