Gene interactions and pathways from curated databases and text-mining

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AKT1 — FOXO4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Tsai et al., Endocrinology 2003 (Carcinoma, Hepatocellular...) : The activity of FOXO proteins is principally regulated by activation of protein kinase B (PKB)/Akt by insulin and other cytokines
Sandri et al., Cell 2004 (Muscular Atrophy) : IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression
Bouchard et al., EMBO J 2004 (Cell Transformation, Neoplastic) : Myc induced proliferation and transformation require Akt mediated phosphorylation of FoxO proteins
Kuiperij et al., Oncogene 2005 : We show that in MEFs cAMP strongly induces transcriptional activation of FoxO4 through the inhibition of PKB
Yang et al., Oncogene 2005 (Cell Transformation, Neoplastic) : Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2 mediated tumorigenicity ... We found that FOXO4A3 inhibited the kinase activity of protein kinase B/Akt and reversed HER2 mediated p27 mislocation in the cytoplasm ... We found that FOXO4A3 inhibited the kinase activity of protein kinase B/Akt and reversed HER2 mediated p27 mislocation in the cytoplasm
Vogt et al., Cell cycle (Georgetown, Tex.) 2005 : Activation of Akt by growth factors results in phosphorylation of nuclear FOXO at specific sites followed by additional phosphorylations mediated by other kinases
Dionne et al., Curr Biol 2006 (Weight Loss) : FOXO activity is inhibited by the insulin effector kinase Akt ; we show that Akt activation is systemically reduced as a result of M. marinum infection
Lavery et al., J Neurosci 2007 : Our results raise the possibility that neurofibroma formation in individuals with neurofibromatosis might result in part from a Ras-PI3K-Akt dependent inhibition of FOXO within Schwann cells
Ni et al., Proc Natl Acad Sci U S A 2007 (Insulin Resistance) : FoxO activated Akt directly interacts with and phosphorylates FoxO, providing feedback inhibition ... In addition, FoxO activity suppresses protein phosphatase 2A (PP2A) and disrupts Akt-PP2A and Akt-calcineurin interactions ... Repression of Akt-PP2A/B interactions and phosphatase activities contributes, at least in part, to FoxO dependent increases in Akt phosphorylation and kinase activity ... Importantly, FoxO mediated increases in Akt activity diminish insulin signaling, as manifested by reduced Akt phosphorylation, reduced membrane translocation of Glut4, and decreased insulin triggered glucose uptake
Evans-Anderson et al., Circ Res 2008 : Likewise, adenoviral mediated expression of AKT promotes cardiomyocyte proliferation and cytoplasmic localization of FOXO
Shankar et al., Journal of molecular signaling 2008 : Inhibition of AKT and MEK kinases synergistically induced FOXO transcriptional activity, which was further enhanced in the presence of EGCG
Park et al., Cell Signal 2009 : In this study, we found that TRAIL inhibited PI3K/Akt dependent FoxO phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells
Gross et al., Curr Diab Rep 2009 : Given the impact of insulin signaling on Akt mediated phosphorylation of FOXO and the relatively high expression of Foxo1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism
Fritz et al., Oncogene 2010 (Breast Neoplasms) : CNK1 controls Akt dependent phosphorylation and transcriptional activity of FoxO , which is a negative regulator of proliferation
Alam et al., Cell Metab 2010 : Thus, EAK-7 and AKT-1 inhibit DAF-16/FoxO activity via distinct mechanisms
Senf et al., Am J Physiol Cell Physiol 2011 : Although the regulation of FOXO by Akt is well evidenced in skeletal muscle, the current study demonstrates that FOXO is also regulated in muscle via the histone acetyltransferase ( HAT ) activities of p300/CREB binding protein (CBP)
Senapedis et al., Mol Biol Cell 2011 : Insulin/Akt activation directs phosphorylation and cytoplasmic sequestration of FOXO away from its target genes and serves as an endpoint of a complex signaling network
Mahajan et al., Thromb Haemost 2012 : In conclusion, thrombin and FoxO factors functionally interact through PI3K/Akt dependent FoxO phosphorylation leading to expression of cell cycle regulating genes and ultimately SMC proliferation
Jacquin et al., Cell Death Differ 2013 : Active Akt prevents FoxO nuclear localization, which precludes Bcl-6 expression and leads to Bcl-xL overexpression