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FOS — SIRT1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: FOS — SIRT1 (direct interaction, pull down) Zhang et al., J Biol Chem 2010*
• IRef Biogrid Interaction: FOS — SIRT1 (direct interaction, enzymatic study) Zhang et al., J Biol Chem 2010*

Text-mined interactions from Literome

Gao et al., Biochem Biophys Res Commun 2008 : These data consistently suggest that SIRT1 directly inhibits the transcriptional activity of AP-1 by targeting c-JUN
Zhang et al., J Biol Chem 2010 : Here we demonstrate that SIRT1 directly interacts with the basic leucine zipper domains of c-Fos and c-Jun, the major components of AP-1, by which SIRT1 suppressed the transcriptional activity of AP-1