◀ Back to CREB1
CREB1 — FOS
Pathways - manually collected, often from reviews:
-
BioCarta oxidative stress induced gene expression via nrf2:
Nrf2/bZip complex (NFE2L2-FOS_JUN_FXYD2_CREB1)
→
bZip (FOS/JUN/FXYD2/CREB1)
(modification, collaborate)
-
BioCarta repression of pain sensation by the transcriptional regulator dream:
c-FOS/c-JUN/CREB/CREB complex (FOS-JUN-CREB1)
→
DREAM/DREAM/DREAM/DREAM complex (CSEN)
(transcription, activates)
-
BioCarta repression of pain sensation by the transcriptional regulator dream:
c-FOS/c-JUN/CREB/CREB complex (FOS-JUN-CREB1)
→
RNA POL II (POLR2A)
(transcription, activates)
-
BioCarta repression of pain sensation by the transcriptional regulator dream:
c-JUN (JUN)
→
c-FOS/c-JUN/CREB/CREB complex (FOS-JUN-CREB1)
(modification, collaborate)
-
BioCarta repression of pain sensation by the transcriptional regulator dream:
c-FOS/c-JUN/CREB/CREB complex (FOS-JUN-CREB1)
→
CREB (CREB1)
(modification, collaborate)
-
BioCarta repression of pain sensation by the transcriptional regulator dream:
c-FOS/c-JUN/CREB/CREB complex (FOS-JUN-CREB1)
→
c-FOS (FOS)
(modification, collaborate)
-
BioCarta repression of pain sensation by the transcriptional regulator dream:
CREB (CREB1)
→
c-FOS (FOS)
(modification, collaborate)
-
FastForward regulation:
CREB1
→
FOS
(transcriptional regulation, unknown)
Huang et al., Nucleic Acids Res 2005*
Evidence: DNABINDING
-
FastForward regulation:
CREB1
→
FOS
(transcriptional regulation, unknown)
Kyttaris et al., J Immunol 2004*, Härtig et al., Nucleic Acids Res 1991*, Kara et al., Mol Cell Biol 1990*, Kwast-Welfeld et al., J Biol Chem 1989*, Tan et al., Mol Cell Biol 1989*
Evidence: DNABINDING
-
WikiPathways Corticotropin-releasing hormone signaling pathway:
CREB1
→
FOS
(mim-transcription-translation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bruning et al., Proc Natl Acad Sci U S A 2000
:
Thus Rsk-2 is required for growth factor stimulated expression of
c-Fos and transcriptional activation of Elk-1 and the serum response factor, but not for
activation of
CREB or the mitogen activated protein kinase pathway in response to PDGF and IGF-1 stimulation
Jeon et al., Immunopharmacology 2000
:
Treatment of DEX to RAW 264.7 cells
induced a dose related inhibition of NF-kappaB/Rel and
AP-1 in chloramphenicol acetyltransferase activity, while neither NF-IL6 nor
CREB/ATF activation was affected by DEX
Shimohata et al., J Neurochem 2005
(Neurodegenerative Diseases) :
The phosphorylation of
cAMP-responsive element binding protein ( CREB ) and
induction of
c-Fos in response to cAMP were strongly suppressed in Neuro2a cells expressing expanded polyglutamine
Forti et al., Mol Cell Biochem 2006
:
However, the cAMP derivatives db-cAMP and 8Br-cAMP, do not promote
CREB phosphorylation and
c-Fos induction in parental Balb3T3 and 3T3-AR transfectants, confirming previous report by others
Kim et al., Proc Natl Acad Sci U S A 2009
(Tetanus) :
In Drosophila motor neurons, induction of
AP-1 , a heterodimer of Fos and Jun,
induces cAMP- and
CREB dependent forms of presynaptic enhancement
Simpson et al., Neuroreport 1994
:
Although forskolin did not alter
CREB-IR , forskolin did
induce striatal P-CREB-IR and
Fos-IR by 2.5- and 10-fold, respectively
Collins-Hicok et al., Mol Cell Biol 1994
:
Both CRE binding protein ( CREB ) and activator protein 1 (AP-1) can regulate RD, but their effects are in opposite directions ;
CREB represses and AP-1 activates RD. CREB induced repression and
AP-1 activation require distinct elements within the control region, but their binding and functions overlap at CRE-3 ...
CREB repression
blocks AP-1 activation in unstimulated cells