Gene interactions and pathways from curated databases and text-mining

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CHUK — FOS

Text-mined interactions from Literome

Chang et al., Exp Cell Res 2002 : This suggests that IL-8 induction by LTbetaR is via TRAFs elicited signaling pathways, including NIK/IKK dependent NF-kappaB activation and ASK/MKK/JNK dependent AP-1 activation
Tsutsumi et al., Virology 2002 : In addition, the activities of c-Jun N-terminal kinase and activator protein-1 (AP-1) , downstream effectors, were enhanced , while IkappaB kinase or nuclear factor-kappaB activities were not enhanced
Krappmann et al., Mol Cell Biol 2004 : The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide induced gene expression and control subordinate activation of AP-1
Song et al., Exp Cell Res 2008 (MAP Kinase Signaling System) : Therefore, we concluded that both IKKalpha and IKKbeta can mediate arsenite induced AP-1 transactivation through NF-kappaB activity independent manner
Chang et al., Nat Med 2009 (Osteoporosis) : Inhibition of IKK-NF-kappaB enhances the expression of Fos related antigen-1 (Fra-1) , an essential transcription factor involved in bone matrix formation in vitro and in vivo