Zaghloul et al., Int J Oncol 2009
(Neovascularization, Pathologic...) :
DC101 treatment elicited increased : 1 ) expression of VEGFR1 and its ligand placental growth factor ; and 2 ) increased Notch activation in tumor vasculature concurrent with expression of the Notch ligand Jagged1
Funahashi et al., Journal of angiogenesis research 2010
:
In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during VEGF-A induced neovascularization
Outtz et al., J Immunol 2010
(Inflammation) :
Thus, both pharmacological inhibition of Notch and genetic analysis demonstrate that Notch1 regulates VEGFR-1 and cytokine expression in macrophages
Krueger et al., Development 2011
:
Thus, Flt1 acts in a Notch dependent manner as a negative regulator of tip cell differentiation and branching