Gene interactions and pathways from curated databases and text-mining

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FGFR3 — MAPK6

Text-mined interactions from Literome

Hart et al., Oncogene 2000 (Cell Transformation, Neoplastic) : Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated by all three ` TDII-like ' FGFR derivatives
Cao et al., Am J Physiol Gastrointest Liver Physiol 2003 (MAP Kinase Signaling System...) : ACh increased MAPK activity and phosphorylation of MAPK and of p38 MAPK
Koziczak et al., Oncogene 2004 (Breast Neoplasms) : The repression of FGFR activity caused downregulation of MAPK in MDA-MB-415 and MDA-MB-453 cells
Easton et al., J Neurochem 2006 (Neuroblastoma) : In addition to Shc, fibroblast growth factor receptor substrate 2 (FRS2) is required for the BDNF induced activation of MAPK
Lamont et al., Br J Cancer 2011 (Carcinoma, Transitional Cell...) : All inhibitors prevented activation of FGFR3 , and inhibited downstream MAPK pathway signalling
Makhnovskiĭ et al., Zh Vyssh Nerv Deiat Im I P Pavlova 2011 : The reversible depression of sensitivity to ACh of command Helix neurons of defensive behavior in the cellular correlate of habituation depends on the decrease in the number of membrane connected ACh receptors as a result of activation of several serine/threonine protein kinases : A, G, CaMKII, p38 MAPK ( without the participation of PKC ), and tyrosine protein kinases including the family of Src-kinases
Jin et al., Hum Mol Genet 2012 (Disease Models, Animal...) : P3 inhibited tyrosine kinase activity of FGFR3 and its typical downstream molecules, extracellular signal regulated kinase/mitogen activated protein kinase
Mavila et al., PloS one 2012 (Liver Neoplasms) : FGF Receptor ( R ) activation resulted in the downstream activation of MAPK , PI3K-AKT, and ß-catenin pathways, as well as cellular proliferation
Kan et al., Mol Pharmacol 1996 : ACh also caused phosphorylation of p42 MAPK and cPLA2, which was inhibited by AG126 ( [ alpha-cyano- ( 3-hydroxy-4-nitro ) cinnamonitrile ] ), a tyrosine kinase inhibitor known to decrease MAPK activity