Gene interactions and pathways from curated databases and text-mining

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FGFR2 — MAPK3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hart et al., Oncogene 2000 (Cell Transformation, Neoplastic) : Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated by all three ` TDII-like ' FGFR derivatives
Jang et al., Blood Cells Mol Dis 2002 (Leukemia...) : Furthermore, overexpression of FGFR2AT-I resulted in increased AKT and MAPK activation, conferring a survival advantage
Koziczak et al., Oncogene 2004 (Breast Neoplasms) : The repression of FGFR activity caused downregulation of MAPK in MDA-MB-415 and MDA-MB-453 cells
Moffa et al., Mol Cancer Res 2004 (Breast Neoplasms...) : FGFR2 expression led to the activation of the mitogen activated protein kinase and phosphatidylinositol 3-kinase signaling cascades
Easton et al., J Neurochem 2006 (Neuroblastoma) : In addition to Shc, fibroblast growth factor receptor substrate 2 (FRS2) is required for the BDNF induced activation of MAPK
Kuslak et al., Differentiation 2007 (MAP Kinase Signaling System) : Blocking FGFR activation with PD173074 showed that activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) in the UGS is dependent on FGFR signaling
Mavila et al., PloS one 2012 (Liver Neoplasms) : FGF Receptor ( R ) activation resulted in the downstream activation of MAPK , PI3K-AKT, and ß-catenin pathways, as well as cellular proliferation