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FGFR2 — MAPK14
Pathways - manually collected, often from reviews:
-
WikiPathways Angiogenesis:
FLT1/FGFR2/TEK/KDR
→
SMAD1/PIK3CA/SRC/PTK2/MAPK14/PLCG1
(activation)
Text-mined interactions from Literome
Hart et al., Oncogene 2000
(Cell Transformation, Neoplastic) :
Phosphorylation of Shp2, PLC-gamma, and
MAPK was also
stimulated by all three ` TDII-like '
FGFR derivatives
Jang et al., Blood Cells Mol Dis 2002
(Leukemia...) :
Furthermore, overexpression of
FGFR2AT-I resulted in increased AKT and
MAPK activation, conferring a survival advantage
Koziczak et al., Oncogene 2004
(Breast Neoplasms) :
The repression of
FGFR activity
caused downregulation of
MAPK in MDA-MB-415 and MDA-MB-453 cells
Moffa et al., Mol Cancer Res 2004
(Breast Neoplasms...) :
FGFR2 expression
led to the activation of the
mitogen activated protein kinase and phosphatidylinositol 3-kinase signaling cascades
Easton et al., J Neurochem 2006
(Neuroblastoma) :
In addition to Shc,
fibroblast growth factor receptor substrate 2 (FRS2) is
required for the BDNF induced activation of
MAPK
Mavila et al., PloS one 2012
(Liver Neoplasms) :
FGF Receptor ( R ) activation
resulted in the downstream activation of
MAPK , PI3K-AKT, and ß-catenin pathways, as well as cellular proliferation