Gene interactions and pathways from curated databases and text-mining

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AKT1 — FGF22

Text-mined interactions from Literome

Yanai et al., Invest Ophthalmol Vis Sci 2002 : Basic fibroblast growth factor , keratinocyte growth factor, nerve growth factor, and hepatocyte growth factor stimulated cell proliferation but did not induce Akt activation or protect the cells from SNP induced apoptosis
Lai et al., Oncogene 2004 (Carcinoma, Squamous Cell...) : Clonal lines of HSulf-1 expressing 012SCC attenuated the activation of ERK/mitogen activated protein kinase ( MAPK ) signaling mediated by fibroblast growth factor ( FGF-2 ) and both ERK/MAPK and Akt signaling mediated by hepatocyte growth factor (HGF)
Kokkinakis et al., J Neuropathol Exp Neurol 2004 (Cell Transformation, Neoplastic) : Western blot analyses demonstrated that MNU exposure caused progressive reduction of p21 protein levels, an increase of Rb phosphorylation, activation of AKT and CDK2, and upregulation of FGF receptors
Azadi et al., Brain Res 2007 (Disease Models, Animal...) : To shed light on the underlying mechanisms, we studied the effects of 9 days ( starting at postnatal day 2 ) in vitro CNTF+BDNF treatment on the endogenous production of CNTF, BDNF, fibroblast growth factor 2 (FGF2), or the activation of extracellular signal regulated kinase ( ERK ), Akt and cAMP-response-element binding protein ( CREB ) in retinal explants
Ito et al., J Lipid Res 2007 : When rat apoE/pcDNA3.his was transfected to transformed rat astrocyte GA-1 cells that otherwise do not synthesize apoE ( GA-1/25 ), FGF-1 did not influence apoE-mRNA, but did increase the apoE secretion and Akt phosphorylation that were suppressed by LY294002
Tassi et al., Am J Physiol Regul Integr Comp Physiol 2007 (Spinal Cord Injuries) : At the molecular level, FGF-BP enhanced FGF2 induced protein tyrosine phosphorylation and AKT/PKB activation ... At the molecular level, FGF-BP enhanced FGF2 induced protein tyrosine phosphorylation and AKT/PKB activation
Kim et al., Growth Factors 2007 : FGF induced a transient activation of ERK, but not Akt , which was inhibited by an inhibitor of MEK, the upstream kinase of ERK, but not by inhibitors of PI3K/Akt ( LY294002 ), epidermal growth factor receptor ( EGFR, AG1478 ), and Src ( PP2 )
Hayashi et al., Genes Cells 2008 : Here, we demonstrate that inhibition of the ERK pathway by the MEK inhibitor U0126 or PD98059 significantly potentiates EGF- and FGF induced Akt phosphorylation at both Thr308 and Ser473 ... We also show that hyperactivation of the ERK pathway greatly attenuates EGF- and FGF induced Akt phosphorylation
Wang et al., Placenta 2009 : Under both normoxia and hypoxia, FGF2 rapidly induced ERK1/2 and AKT1 phosphorylation, while VEGF induced ERK1/2, but not AKT1 phosphorylation
Dey et al., Cancer Res 2010 (Lung Neoplasms...) : Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
Tsai et al., Biochem Pharmacol 2012 : While FGF did not enhance the phosphorylation of AKT in the CTR1 ( +/+ ) cells, both PDGF and EGF increased pAKT in the CTR1 ( +/+ ) but not CTR1 ( -/- ) cells