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FBXO32 — IGF1

Text-mined interactions from Literome

Sacheck et al., Am J Physiol Endocrinol Metab 2004 (Insulin Resistance...) : IGF-I rapidly reduced atrogin-1 expression within 1 h by blocking mRNA synthesis without affecting mRNA degradation, whereas IGF-I decreased MuRF1 mRNA slowly ... IGF-I activates the phosphatidylinositol 3-kinase (PI3K)-Akt pathway, and inhibition of this pathway [ but not the calcineurin-nuclear factor of activated T cell ( NFAT ) or the MEK-ERK pathway ] increased proteolysis and atrogin-1 mRNA expression
Frost et al., Am J Physiol Endocrinol Metab 2007 (Sepsis) : Whereas the sepsis induced increase in atrogin-1 expression was completely prevented by IGF-I , the increased MuRF1 was not altered
Glass et al., Curr Opin Clin Nutr Metab Care 2010 (Cachexia...) : The insulin-like growth factor-1 can block the transcriptional upregulation of MuRF1 and MAFbx via the phosphatidylinositol-3 kinase/Akt/Foxo pathway
Bower et al., Biochem Biophys Res Commun 2010 : In starved cells, MAFbx-alpha mRNA levels declined in response to amino acid, IGF-I and IGF-II treatments whereas MAFbx-beta levels only decreased in response to IGF-I
López-Menduiña et al., Am J Physiol Regul Integr Comp Physiol 2010 (Arthritis, Experimental...) : IGF-I attenuated the arthritis induced increase in atrogin-1 and MuRF1 expression in the gastrocnemius, whereas it did not modify the expression of these genes in the soleus muscle