Gene interactions and pathways from curated databases and text-mining

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AKT1 — FBXO32

Text-mined interactions from Literome

Sandri et al., Cell 2004 (Muscular Atrophy) : IGF-1 treatment or AKT overexpression inhibits Foxo and atrogin-1 expression
Stitt et al., Mol Cell 2004 (Muscular Atrophy) : Moreover, the mechanism for this inhibition involves Akt mediated inhibition of the FoxO family of transcription factors ; a mutant form of FOXO1, which prevents Akt phosphorylation, thereby prevents Akt mediated inhibition of MuRF1 and MAFbx upregulation
Li et al., J Clin Invest 2007 (Cardiomegaly) : Our results indicate that atrogin-1 does not affect the activity of Akt itself, but serves as a coactivator for members of the Forkhead family of transcription factors that function downstream of Akt
Zhang et al., Circ Res 2010 (Diabetes Mellitus) : Moreover, inhibition of Akt signaling attenuated the phosphorylation of forkhead box O transcription factor ( FOXO)-3a and enhanced atrogin-1 expression, which in turn suppressed BK-ß ( 1 ) protein levels in human CASMCs