Gene interactions and pathways from curated databases and text-mining

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AKT1 — F2RL1

Text-mined interactions from Literome

Tanaka et al., Biochem Biophys Res Commun 2008 : The PAR2 triggered IL-8 release was suppressed by inhibitors of MEK ( U0126 ) or PI3-kinase ( LY294002 ), and PAR2 stimulation indeed activated the downstream kinases, ERK and Akt
Moriyuki et al., J Pharmacol Sci 2009 : Stimulation of PAR2 also caused phosphorylation of Akt , an effect suppressed by inhibitors of PI3-kinase and MEK
Chang et al., Am J Pathol 2013 (Neovascularization, Pathologic...) : Diminishing ILK by siRNA decreased the levels of PAR-2 induced p-AKT , HIFs-a, and TGF-a ; our results suggest that ILK is involved in the PAR-2 mediated TGF-a via an HIF-a dependent pathway