Gene interactions and pathways from curated databases and text-mining

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AKT1 — EZH2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Cha et al., Science 2005 (Cell Transformation, Neoplastic) : Akt mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3
Roy et al., Cell death & disease 2012 : This process was found to be Akt dependent, and inhibition or overexpression of Akt lead to concurrent changes in EZH2 levels
Ferraro et al., Int J Biochem Cell Biol 2013 (Cell Transformation, Neoplastic...) : EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells
Chen et al., Cell cycle (Georgetown, Tex.) 2013 : JNK and STAT3 signaling pathways converge on Akt mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic