Gene interactions and pathways from curated databases and text-mining

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ETS2 — HIF1A

Text-mined interactions from Literome

Spinella et al., Cancer Res 2007 (Melanoma...) : ETs also increase HIF-1alpha expression under both normoxic and hypoxic conditions and its silencing by siRNA desensitizes COX-2 transcriptional activity, PGE ( 2 ) and VEGF production, and MMP activation in response to ET-3, implicating, for the first time, HIF-1alpha/COX as downstream targets of ET ( B ) R signaling leading to invasiveness
Spinella et al., PloS one 2010 (Melanoma...) : Here we found that in melanoma cells ET-1, ET-2, and ET-3 through ET ( B ) R, enhance the expression and activity of HIF-1alpha and HIF-2alpha that in turn regulate the expression of vascular endothelial growth factor ( VEGF ) in response to ETs or hypoxia