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ETS2 — HIF1A
Text-mined interactions from Literome
Spinella et al., Cancer Res 2007
(Melanoma...) :
ETs also
increase HIF-1alpha expression under both normoxic and hypoxic conditions and its silencing by siRNA desensitizes COX-2 transcriptional activity, PGE ( 2 ) and VEGF production, and MMP activation in response to ET-3, implicating, for the first time,
HIF-1alpha/COX as downstream targets of ET ( B ) R signaling leading to invasiveness
Spinella et al., PloS one 2010
(Melanoma...) :
Here we found that in melanoma cells ET-1, ET-2, and ET-3 through ET ( B ) R, enhance the expression and activity of
HIF-1alpha and HIF-2alpha that in turn regulate the expression of vascular endothelial growth factor ( VEGF ) in
response to
ETs or hypoxia