Gene interactions and pathways from curated databases and text-mining

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ETS1 — MAPK14

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Berti-Mattera et al., J Neurochem 2000 : Similar effects of ETs on AA release and MAPK activity were observed in cultures expanded from primary SC and in iSC
Foulds et al., Mol Cell Biol 2004 : Ras/mitogen activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
Beh et al., Development 2007 : In ascidian embryos, FGF/MAPK mediated activation of the transcription factor Ets1/2 is required for heart tissue specification and cell migration
Ghosh et al., J Biol Chem 2012 (MAP Kinase Signaling System...) : Therefore, based on these observations, it is hypothesized that the activation of PI3K/AKT and p38 MAPK by VEGF results in ETS-1 gene expression, which activates MMP-9 and MMP-13, leading to the invasion and scattering of SKOV-3 cells
Woznica et al., Dev Biol 2012 : The Ciona heart progenitor lineage is first specified by Fibroblast Growth Factor/Map Kinase ( FGF/MapK ) activation of the transcription factor Ets1/2 ( Ets )