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ESR2 — NOS1

Text-mined interactions from Literome

Zhu et al., Science 2002 (Hypertension) : In wild-type mouse blood vessels, estrogen attenuates vasoconstriction by an ERbeta mediated increase in inducible nitric oxide synthase expression
Simoncini et al., Arterioscler Thromb Vasc Biol 2003 : By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide synthase activity
Xia et al., Endocrinology 2004 (Neuroblastoma) : These results demonstrate that E2-stimulated NO production occurs via estrogen receptor mediated activation of the constitutive NOSs, neuronal NOS and eNOS
Gingerich et al., Neuropharmacology 2008 : Activation of ERbeta increases levels of phosphorylated nNOS and NO production through a Src/PI3K/Akt dependent pathway in hypothalamic neurons ... Because phosphorylation of nNOS at Ser ( 1412 ) increases nNOS activity which leads to increased NO production, we investigated the effects of ERbeta activation on nNOS phosphorylation at Ser ( 1412 ) and NO production in primary hypothalamic neurons ... Using the selective ERbeta agonist, DPN ( 10nM ), we show that activation of ERbeta rapidly increases phosphorylation levels of nNOS at Ser ( 1412 ) and NO production ... Finally, we demonstrate that Src kinase acts upstream of the PI3K/Akt pathway based on our finding that the selective Src inhibitor, PP2 ( 10microM ), blocked the increases in nNOS phosphorylation levels, NO production, and PI3K/Akt activity induced by ERbeta activation ... Together, our results show that Src kinase mediates ERbeta induced increases in phosphorylation levels of nNOS at Ser ( 1412 ) and NO production by activating the PI3K/Akt pathway
Cignarella et al., J Pharmacol Exp Ther 2009 (Diabetes Mellitus, Experimental...) : Distinct roles of estrogen receptor-alpha and beta in the modulation of vascular inducible nitric-oxide synthase in diabetes