Gene interactions and pathways from curated databases and text-mining

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AKT1 — ESR2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Martin et al., Endocrinology 2000 : Studies using mutants of ER-alpha demonstrated that Akt increased estrogen receptor activity through the amino-terminal activation function-1 (AF-1)
Zhang et al., Neuroreport 2001 (Alzheimer Disease) : These results indicate that the neuroprotective effects of E2 may be mediated at least in part via estrogen receptor mediated protein kinase B activation
Simoncini et al., Arterioscler Thromb Vasc Biol 2003 : By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide synthase activity
Vallejo et al., Mol Endocrinol 2005 : Here we report that the proliferative response of UIII rat uterine stromal cells to a short treatment with progestins requires active progesterone receptor (PR) and estrogen receptor beta (ERbeta) as well as a rapid and transient activation of Erk1-2 and Akt signaling
Duong et al., Cancer Res 2006 (Breast Neoplasms) : AKT regulation of estrogen receptor beta transcriptional activity in breast cancer ... Given the importance of coactivators in ER transcriptional activity, we further investigated the possible involvement of steroid receptor coactivator 1 (SRC1) and glucocorticoid receptor interacting protein 1 ( GRIP1 ) in AKT regulation of ER beta
Lehnes et al., Endocrinology 2007 (Cell Transformation, Neoplastic) : Cumulatively, our results suggest that Akt1 and ErbB2 are involved in in vivo tumorigenesis and modulation of estrogen receptor-alpha expression and activity
Tissier et al., J Mol Cell Cardiol 2007 (Myocardial Infarction...) : In conclusion, genistein exerts pharmacological postconditioning with a similar potency as 17beta-estradiol through a pathway involving activation of the estrogen receptor , of PI3K/Akt and mitochondrial preservation
Boland et al., Steroids 2008 : ERbeta plays a major role in the inhibition of apoptosis by 17beta-estradiol at the level of mitochondria, whereas ERalpha and ERbeta mediate the activation of Akt to the same extent, suggesting differential involvement of ER isoforms depending on the step of the apoptotic/survival pathway involved
Liu et al., Toxicol Appl Pharmacol 2008 (Breast Neoplasms) : It is concluded that Cd, like estradiol, can cause rapid activation of ERK1/2 and AKT and that these signaling events are mediated by possible interaction with membrane ER alpha and GPR30, but not ER beta
Wang et al., Biochim Biophys Acta 2008 (Breast Neoplasms) : The estrogen receptor interacting protein HPIP increases estrogen-responsive gene expression through activation of MAPK and AKT ... Here, we report that hematopoietic PBX interacting protein ( HPIP ) interacts both with ERalpha and with ERbeta , and increases ERalpha target gene expression through activation of MAPK and AKT and enhanced ERalpha phosphorylation
Gingerich et al., Neuropharmacology 2008 : Finally, we demonstrate that Src kinase acts upstream of the PI3K/Akt pathway based on our finding that the selective Src inhibitor, PP2 ( 10microM ), blocked the increases in nNOS phosphorylation levels, NO production, and PI3K/Akt activity induced by ERbeta activation
Hwang et al., Toxicol Appl Pharmacol 2008 : Mechanism of phytoestrogen puerarin mediated cytoprotection following oxidative injury : estrogen receptor dependent up-regulation of PI3K/Akt and HO-1
Papa et al., J Cell Sci 2011 : Upon IMS stress, overproduction of reactive oxygen species ( ROS ) and phosphorylation of AKT triggers estrogen receptor ( ER ) activity, which further upregulates the transcription of the mitochondrial regulator NRF1 and the IMS protease OMI ( officially known as HTRA2 )
Hwang et al., Toxicol Appl Pharmacol 2011 : These results indicate that puerarin stimulates eNOS phosphorylation and NO production via activation of an estrogen receptor mediated PI3K/Akt- and CaMKII/AMPK dependent pathway
Jain et al., Nanomedicine (Lond) 2012 (MAP Kinase Signaling System) : Our findings demonstrate that in vitro cadmium containing QDs induce cellular proliferation, estrogen receptor a activation , and biphasic phosphorylation of AKT and ERK1/2, comparable with 17ß-estradiol
Hashimoto et al., Evidence-based complementary and alternative medicine : eCAM 2012 : These results suggest that ginsenoside Rb1 protects PC12 cells from caspase-3 dependent apoptosis through stimulation of estrogen receptor with consequent activation of ERK1/2 and Akt and inhibition of SAPK/JNK and p38