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AKT1 — ESR2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Martin et al., Endocrinology 2000
:
Studies using mutants of ER-alpha demonstrated that
Akt increased
estrogen receptor activity through the amino-terminal activation function-1 (AF-1)
Zhang et al., Neuroreport 2001
(Alzheimer Disease) :
These results indicate that the neuroprotective effects of E2 may be mediated at least in part via
estrogen receptor mediated
protein kinase B activation
Simoncini et al., Arterioscler Thromb Vasc Biol 2003
:
By interacting with phosphatidylinositol 3-kinase (PI3K),
estrogen receptor (ER) alpha
leads to activation of protein kinase
Akt and to subsequent increase in endothelial nitric oxide synthase activity
Vallejo et al., Mol Endocrinol 2005
:
Here we report that the proliferative response of UIII rat uterine stromal cells to a short treatment with progestins requires active progesterone receptor (PR) and
estrogen receptor beta (ERbeta) as well as a rapid and transient
activation of Erk1-2 and
Akt signaling
Duong et al., Cancer Res 2006
(Breast Neoplasms) :
AKT regulation of
estrogen receptor beta transcriptional activity in breast cancer ... Given the importance of coactivators in ER transcriptional activity, we further investigated the possible involvement of steroid receptor coactivator 1 (SRC1) and glucocorticoid receptor interacting protein 1 ( GRIP1 ) in
AKT regulation of
ER beta
Lehnes et al., Endocrinology 2007
(Cell Transformation, Neoplastic) :
Cumulatively, our results suggest that
Akt1 and ErbB2 are
involved in in vivo tumorigenesis and modulation of
estrogen receptor-alpha expression and activity
Tissier et al., J Mol Cell Cardiol 2007
(Myocardial Infarction...) :
In conclusion, genistein exerts pharmacological postconditioning with a similar potency as 17beta-estradiol through a pathway involving
activation of the
estrogen receptor , of
PI3K/Akt and mitochondrial preservation
Boland et al., Steroids 2008
:
ERbeta plays a major role in the inhibition of apoptosis by 17beta-estradiol at the level of mitochondria, whereas ERalpha and
ERbeta mediate the activation of
Akt to the same extent, suggesting differential involvement of ER isoforms depending on the step of the apoptotic/survival pathway involved
Liu et al., Toxicol Appl Pharmacol 2008
(Breast Neoplasms) :
It is concluded that Cd, like estradiol, can cause rapid activation of ERK1/2 and
AKT and that these signaling events are
mediated by possible interaction with membrane ER alpha and GPR30, but not
ER beta
Wang et al., Biochim Biophys Acta 2008
(Breast Neoplasms) :
The
estrogen receptor interacting protein HPIP
increases estrogen-responsive gene expression through activation of MAPK and
AKT ... Here, we report that hematopoietic PBX interacting protein ( HPIP ) interacts both with ERalpha and with
ERbeta , and
increases ERalpha target gene expression through activation of MAPK and
AKT and enhanced ERalpha phosphorylation
Gingerich et al., Neuropharmacology 2008
:
Finally, we demonstrate that Src kinase acts upstream of the PI3K/Akt pathway based on our finding that the selective Src inhibitor, PP2 ( 10microM ), blocked the increases in nNOS phosphorylation levels, NO production, and
PI3K/Akt activity
induced by
ERbeta activation
Hwang et al., Toxicol Appl Pharmacol 2008
:
Mechanism of phytoestrogen puerarin mediated cytoprotection following oxidative injury :
estrogen receptor dependent up-regulation of
PI3K/Akt and HO-1
Papa et al., J Cell Sci 2011
:
Upon IMS stress, overproduction of reactive oxygen species ( ROS ) and phosphorylation of
AKT triggers
estrogen receptor ( ER ) activity, which further upregulates the transcription of the mitochondrial regulator NRF1 and the IMS protease OMI ( officially known as HTRA2 )
Hwang et al., Toxicol Appl Pharmacol 2011
:
These results indicate that puerarin stimulates eNOS phosphorylation and NO production via activation of an
estrogen receptor mediated
PI3K/Akt- and CaMKII/AMPK dependent pathway
Jain et al., Nanomedicine (Lond) 2012
(MAP Kinase Signaling System) :
Our findings demonstrate that in vitro cadmium containing QDs induce cellular proliferation,
estrogen receptor a
activation , and biphasic phosphorylation of
AKT and ERK1/2, comparable with 17ß-estradiol
Hashimoto et al., Evidence-based complementary and alternative medicine : eCAM 2012
:
These results suggest that ginsenoside Rb1 protects PC12 cells from caspase-3 dependent apoptosis through
stimulation of
estrogen receptor with consequent activation of ERK1/2 and
Akt and inhibition of SAPK/JNK and p38