Gene interactions and pathways from curated databases and text-mining

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ESAT — TLR4

Text-mined interactions from Literome

Pathak et al., Nat Immunol 2007 : Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages
Yu et al., Cell Signal 2012 : ESAT-6 mediated autophagosome formation and TLR signaling deviation lead to abnormal activation of NF-?B and subsequent erroneous expression of NF-?B dependent genes