Gene interactions and pathways from curated databases and text-mining

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ERBB2 — MAPK14

Text-mined interactions from Literome

Badache et al., Cancer Res 2001 (Breast Neoplasms...) : Down-regulation of ErbB receptor activity, through the use of specific pharmacological inhibitors or dominant negative receptor constructs, revealed that IL-6 induced MAPK activation was largely dependent on epidermal growth factor (EGF) receptor activity, but not on ErbB-2 activity
Deb et al., J Biol Chem 2001 : The kinase activity, but not tyrosine phosphorylation, of ErbB2 was required for EGF induced MAPK activation
Bowers et al., Oncogene 2001 (Breast Neoplasms...) : Inhibiting ErbB2 caused an enhanced MAPK response simulating an amplified ErbB1 ( or 4 ) response
Kiguchi et al., Cancer Res 2001 (Adenocarcinoma...) : Increased ErbB-2/epidermal growth factor receptor heterodimer formation, activation of mitogen activated protein kinase , and up-regulation of cyclooxygenase-2 levels ( mRNA and protein ) were observed in gallbladder epithelium of these mice
Vijapurkar et al., Exp Cell Res 2003 (Cell Transformation, Neoplastic...) : Roles of mitogen activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor mediated heregulin signaling
Lu et al., Biochem Biophys Res Commun 2004 (Breast Neoplasms...) : We report that the overexpression of ErbB2 inhibits IGF-I induced MAPK signaling ... In SKBR3/IGF-IR cells, reduction of ErbB2 by antisense methodology restores the IGF-I induced MAPK activation
Benlimame et al., J Cell Biol 2005 (Cell Transformation, Neoplastic...) : ErbB induced oncogenic transformation correlates with the ability of FAK to restore ErbB-2/3 induced mitogen activated protein kinase ( MAPK ) activation ; the inhibition of MAPK prevented oncogenic transformation
Gunawardane et al., Cancer Res 2005 (Breast Neoplasms...) : Constitutive activation of the extracellular signal regulated kinase ( ERK ) pathway also enhanced PDEF induced motility and invasion, suggesting that activation of the ERK/mitogen activated protein kinase by ErbB2 and CSF-1R/CSF-1 can cooperate with PDEF to promote motility and invasion
Fan et al., J Biol Chem 2008 : Expression of the activated ErbB2 mutants in cells resulted in elevated ligand independent ErbB2 autophosphorylation, ErbB3 phosphorylation, and stimulation of mitogen activated protein kinase
Xiang et al., Proc Natl Acad Sci U S A 2008 (Breast Neoplasms...) : Expression of Brk enhances the ErbB2 induced activation of Ras/MAPK signaling and cyclin E/cdk2 activity to induce cell proliferation of mammary 3-dimensional acini in culture
Kim et al., Cancer Lett 2009 (MAP Kinase Signaling System...) : Overexpression of ErbB2 significantly activated p38 MAPK and Akt, while Raf-1/MEK/ERK pathway was not activated by ErbB2
Zhou et al., Zhonghua Yi Xue Za Zhi 2012 (MAP Kinase Signaling System) : After a pretreatment of antibodies of ErbB2 , ErbB3, inhibitors of p38MAPK , ERK1/2, MSK1 and antibody of CREB and a stimulation of NRG-1ß, the expression of MUC5AC decreased ( 0.221 ± 0.033, 0.238 ± 0.044, 0.386 ± 0.021, 0.352 ± 0.022, 0.294 ± 0.017, 0.252 ± 0.019 ) versus the NRG-1ß group ( 0.650 ± 0.134 )
Marte et al., Oncogene 1995 : Activation of ErbB-2 by point mutation, or by monoclonal antibodies, also stimulates both the MAPK and the p70/p85 S6 kinase pathways