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ERBB2 — IGF1
Pathways - manually collected, often from reviews:
-
KEGG Focal adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC
→
EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB
(protein-protein, activation)
-
KEGG Prostate cancer:
EGF/IGF1/INS/PDGFA/PDGFB/PDGFC/PDGFD/TGFA
→
EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB
(protein-protein, activation)
-
WikiPathways Focal Adhesion:
EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC
→
BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1
(activation)
Text-mined interactions from Literome
Balañá et al., Oncogene 2001
(Mammary Neoplasms, Experimental) :
These results show the existence of a hierarchical interaction between IGF-IR and ErbB-2, by means of which
IGF-IR directs
ErbB-2 phosphorylation ... This hetero-oligomer was also found in MCF-7 human breast cancer cells in which association of IGF-IR and
ErbB-2 was
induced by heregulin and
IGF-I
Dokmanovic et al., Mol Cancer Ther 2011
(Breast Neoplasms) :
In particular, treatment of SKBR3 cells with recombinant IGFBP-3 blocks
IGF-I induced activation of IGF-IR and
ErbB2 , and stable expression of IGFBP-3 inhibits SKBR3 cell growth