Gene interactions and pathways from curated databases and text-mining

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ERBB2 — IGF1

Pathways - manually collected, often from reviews:

  • KEGG Focal adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC → EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB (protein-protein, activation)
  • KEGG Prostate cancer: EGF/IGF1/INS/PDGFA/PDGFB/PDGFC/PDGFD/TGFA → EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB (protein-protein, activation)
  • WikiPathways Focal Adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC → BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 (activation)

Text-mined interactions from Literome

Balañá et al., Oncogene 2001 (Mammary Neoplasms, Experimental) : These results show the existence of a hierarchical interaction between IGF-IR and ErbB-2, by means of which IGF-IR directs ErbB-2 phosphorylation ... This hetero-oligomer was also found in MCF-7 human breast cancer cells in which association of IGF-IR and ErbB-2 was induced by heregulin and IGF-I
Dokmanovic et al., Mol Cancer Ther 2011 (Breast Neoplasms) : In particular, treatment of SKBR3 cells with recombinant IGFBP-3 blocks IGF-I induced activation of IGF-IR and ErbB2 , and stable expression of IGFBP-3 inhibits SKBR3 cell growth