Gene interactions and pathways from curated databases and text-mining

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EPO — STAT3

Text-mined interactions from Literome

Millot et al., Br J Haematol 2001 : Interestingly, while Stat5, but not Stat3 , was activated in erythroid cells in response to erythropoietin (EPO) , both were activated in erythroid and granulocytic cells stimulated by G-CSF
Kirito et al., Blood 2002 (Leukemia) : To clarify the mechanism by which EPO activates Stat1 and Stat3 via the EPO receptor (EPOR), a series of chimeric receptors was constructed bearing the extracellular domain of the granulocyte colony stimulating factor receptor linked to the transmembrane domain of EPOR and the full length or several mutants of the cytoplasmic domain of EPOR, and these chimeric receptor complementary DNAs were introduced into UT-7/EPO cells
Kirito et al., Int J Hematol 2002 (Leukemia, Erythroblastic, Acute) : Previously, we demonstrated that Stat1 and Stat3 are activated by erythropoietin (EPO) in a human EPO dependent erythroleukemia cell line UT-7/EPO
Bramey et al., BMC gastroenterology 2009 (Reperfusion Injury) : Both, in the cultured rat hepatocytes ( 10 U/ml for 15 minutes ) and in the rat liver perfused in situ with rHu-EPO ( 8.9 U/ml for 15 minutes ) no evidence for EPO dependent signalling was found as indicated by missing effects of rHu-EPO on phosphorylation of JAK-2, STAT-3 and STAT-5 and on the induction of Bcl-2 mRNA
Wincewicz et al., Folia Histochem Cytobiol 2009 (Breast Neoplasms...) : STAT3 and hypoxia induced proteins -- HIF-1alpha, EPO and EPOR in relation with Bax and Bcl-xL in nodal metastases of ductal breast cancers ... STAT3 contributes to increase of EPO expression which is also HIF-1 dependent
Wang et al., Am J Pathol 2012 (Retinal Neovascularization) : Inhibition of STAT3 reduced avascular retina and increased retinal erythropoietin (Epo) expression ... The mechanism by which activated STAT3 regulated Epo was by inhibition of Epo promoter activity
McCloskey et al., Invest Ophthalmol Vis Sci 2013 (Body Weight...) : Erythropoietin or VEGF stimulated hRMVEC proliferation and STAT3 activation
Kirito et al., J Biol Chem 1997 : This indicates that IL-3, GM-CSF, and EPO commonly activated Stat1alpha, Stat3 , and Stat5 proteins in UT-7
Miura et al., Acta Haematol 1998 (Leukemia...) : In UT-7 cells, both GM-CSF and EPO induced the activation of Stat1 alpha, Stat3 and Stat5 ... In addition, GM-CSF inhibited EPO induced erythroid differentiation and concomitantly activated Stat1 alpha and Stat3 in UT-7/GM cells even in the presence of EPO