Gene interactions and pathways from curated databases and text-mining

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EPO — MAPK3

Text-mined interactions from Literome

Bittorf et al., Biol Chem 1999 (Leukemia, Erythroblastic, Acute) : In conclusion, SHP1 regulates the transcriptional activity stimulated by the EPO induced JAK/STAT and MAPK pathways and is involved in the signaling machinery responsible for erythroid differentiation and suppression of apoptosis
Sakamoto et al., J Biol Chem 2000 : However, EPO dependent mitogen activated protein ( MAP ) kinase activation was observed in T-JJER and BF-ER cells but not in T-JER cells
Kadri et al., Cell Growth Differ 2000 (MAP Kinase Signaling System) : Erythropoietin induction of tissue inhibitors of metalloproteinase-1 expression and secretion is mediated by mitogen activated protein kinase and phosphatidylinositol 3-kinase pathways
Akimoto et al., J Hypertens 2001 : Human recombinant erythropoietin ( rHuEPO ) induces cytosolic free calcium ( [ Ca2+ ] i ) mobilization, an activation of mitogen activated protein ( MAP ) kinase and DNA synthesis in several tissues
Kusano et al., Kidney Blood Press Res 2001 : Modulation of endothelin-1 induced cytosolic free calcium mobilization and mitogen activated protein kinase activation by erythropoietin in vascular smooth muscle cells
Ito et al., Am J Physiol Cell Physiol 2002 : We therefore hypothesized that cAMP effectors inhibit Epo induced MAPK activation in rat VSMC ... These results indicated that cAMP inhibited Epo induced MAPK activation and that this suppression might be regulated upstream or at Raf-1
Schaefer et al., Cell Signal 2004 (Leukemia, Erythroblastic, Acute...) : The effect of erythropoietin (Epo) on the expression of mitogen activated protein kinase ( MAPK ) target genes egr-1 and c-fos was investigated in Epo-responsive murine erythroblastic cell line ELM-I-1
Lester et al., J Biol Chem 2005 (Breast Neoplasms...) : In this study, we have shown that erythropoietin (Epo) activates the mitogen activated protein kinase , extracellular signal regulated kinase ( ERK ), and promotes migration in MCF-7 breast cancer cells
Fukumoto et al., Cell Signal 2009 (Leukemia, Erythroblastic, Acute) : EPO induced activation of Erk1/2 but not of Akt was significantly suppressed in F-36P-Gab1-siRNA cells compared with mock transfected F-36P cells
Chen et al., Exp Cell Res 2010 : This effect of EPO was partially mediated by a mitogen activated protein kinase dependent inhibition of Smad signal transduction
Genc et al., Cell Biochem Funct 2010 : These results suggest that Epo induces neural HO-1 expression through the activation of PI3K, MAPK , and Nrf2 pathways, and this may unveil a novel mechanism which mediates the cytoprotective responses elicited by Epo
Perna et al., Blood 2010 (MAP Kinase Signaling System...) : Indeed, L3MBTL1 knockdown enhanced the sensitivity of hematopoietic stem/progenitor cells to erythropoietin (Epo), with increased Epo induced phosphorylation of STAT5, AKT, and MAPK as well as detectable phosphorylation in the absence of Epo
Frisan et al., Haematologica 2010 (Myelodysplastic Syndromes) : Erythropoietin dependent proliferation and survival, and phospho ( p ) -ERK1/2 expression in steady state and after erythropoietin stimulation were defective in cultured erythroblasts
Klingmüller et al., Proc Natl Acad Sci U S A 1997 : This cascade involves sequential EPO induced recruitment of PI3 kinase to the EPO-R and activation of mitogen activated protein kinase activity, independent of the Shc/Grb2-adapter pathway and of STAT5
Sui et al., Blood 1998 : Wortmannin only inhibits MAPK activation induced by EPO but not that by SCF, suggesting that SCF and EPO may activate MAPK through different pathways, which would facilitate synergy
Nagata et al., Blood 1998 (Leukemia, Erythroblastic, Acute) : We found that all MAP kinases examined, ERK1 , ERK2, p38, JNK1, and JNK2, were rapidly and transiently activated by erythropoietin (Epo) stimulation in SKT6 cells, which can be induced to differentiate into hemoglobinized cells in response to Epo