◀ Back to MAPK3
EPHA8 — MAPK3
Text-mined interactions from Literome
Gu et al., Oncogene 2005
(Brain Neoplasms...) :
Consistent with these results,
EphA8 expression
induced a sustained increase in the activity of
MAPK , whereas ligand mediated EphA8 activation had no further modulatory effects on MAP kinase activity ... Consistent with these results, EphA8 expression
induced a sustained increase in the activity of
MAPK , whereas ligand mediated
EphA8 activation had no further modulatory effects on MAP kinase activity
Nie et al., Nat Neurosci 2010
:
We also found that
EphA receptor activation by ephrin-A ligands in neurons
led to inhibition of
extracellular signal regulated kinase 1/2 ( ERK1/2 ) activity and decreased inhibition of Tsc2 by ERK1/2
Day et al., Cancer Cell 2013
(Brain Neoplasms...) :
Importantly,
EphA3 is highly expressed on the tumor initiating cell population in glioma and appears critically
involved in maintaining tumor cells in a less differentiated state by modulating
mitogen activated protein kinase signaling