Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
HIF1A
→
EP300
(directlyIncreases, EP300 Activity)
Evidence: O2-dependent hydroxylation of asparagine (N) residue 803 in HIF-1a by the enzyme FIH-1 (factor inhibiting HIF-1) blocks the binding of p300 and CBP to HIF-1a and therefore inhibits HIF-1-mediated gene transcription.
OpenBEL Selventa BEL large corpus:
HIF1A
→
EP300
(directlyIncreases, EP300 Activity)
Evidence: In addition to effects on HIF-1a synthesis, activation of the RAF MEK ERK signalling pathway has also been shown to stimulate HIF-1a transactivation-domain function. This effect is due at least in part to phosphorylation by ERK of the co-activator p300, with which the transactivation domains interact.
OpenBEL Selventa BEL large corpus:
EP300
→
HIF1A
(increases, HIF1A Activity, EP300 Activity)
Evidence: stabilized HIF1A is translocated to the nucleus, where it interacts with cofactors such as ARNT, CBP/p300 and the DNA polymerase II complex to bind to hypoxia-responsive elements and activate transcription of target genes