Gene interactions and pathways from curated databases and text-mining

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ELN — IGF1

Text-mined interactions from Literome

Bunda et al., Am J Pathol 2007 : Aldosterone induces elastin production in cardiac fibroblasts through activation of insulin-like growth factor-I receptors in a mineralocorticoid receptor independent manner
Burkhardt et al., Placenta 2009 (Fetal Growth Retardation...) : Serum levels of IGF-I , a regulator of elastin synthesis, were significantly lower in IUGR cord blood ( P < 0.01 ) than in AGA cord blood
Noguchi et al., Pediatr Res 1991 : IGF-I stimulates tropoelastin synthesis in neonatal rat pulmonary fibroblasts ... We have examined the effect of IGF-I on tropoelastin (TE) synthesis in cultured rat neonatal pulmonary fibroblasts, because this growth factor has been shown to stimulate TE synthesis in vascular smooth muscle cells
Sesso et al., Am J Hypertens 2010 (Birth Weight...) : Small-for-gestational-age children exhibited elevated amounts of MMP-2, MMP-9, MMP-2/TIMP-2 ratio, MMP-9/TIMP-2 ratio, as well as lower concentration of IGF-I ( P < 0.01 ), a known regulator of elastin synthesis
Badesch et al., Biochem Biophys Res Commun 1989 : Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells ... Insulin-like growth factor I stimulates mitogenesis in smooth muscle cells, and upregulates elastin synthesis in embryonic aortic tissue ... Therefore, we studied the effect of IGF-I on elastin and total protein synthesis by pulmonary arterial smooth muscle cells in vitro
Foster et al., Coll Relat Res 1987 : Insulin-like growth factor I , somatomedin C, induces the synthesis of tropoelastin in aortic tissue
Jensen et al., J Biol Chem 1995 : Transcriptional regulation of the elastin gene by insulin-like growth factor-I involves disruption of Sp1 binding
Wolfe et al., J Biol Chem 1993 : Insulin-like growth factor-I regulates transcription of the elastin gene