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ELK1 — MAPK3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ELK1 → MAPK3 (directlyIncreases, MAPK3 Activity, ELK1 Activity) Hayashi et al., J Biol Chem 2006*
  Evidence: It is known that there are two isoforms of ERK, ERK1 and ERK2, and they phosphorylate and activate various transcription factors, such as Elk-1 and Elk-2. These transcription factors regulate expression of diverse genes that relates to the proliferation and growth of the cells.
• OpenBEL Selventa BEL large corpus: ELK1 → MAPK3 (directlyIncreases, ELK1 Activity)
  Evidence: Activated ERK can translocate into the nucleus, where it catalyses the phosphorylation of transcription factors such as p62TCF, initiating a transcriptional programme that leads to cellular proliferation or differentiation.
• OpenBEL Selventa BEL large corpus: ELK1 → MAPK3 (directlyIncreases, ELK1 Activity)
  Evidence: 9130707;8548291;8262053;11145955;11309409;8887554
• OpenBEL Selventa BEL large corpus: ELK1 → MAPK3 (directlyIncreases, ELK1 Activity) Gille et al., Curr Biol 1995*
  Evidence: The major phosphopeptide detected with p46SAPK and with p54SAPK is similar in mobility to a major phosphopeptide in the ERK1 map (Fig. 4b). This peptide was previously demonstrated to contain phosphoserine at position 383 [8].
• OpenBEL Selventa BEL large corpus: ELK1 → MAPK3 (directlyIncreases, ELK1 Activity) Duan et al., J Biol Chem 2001*
  Evidence: Subsequent studies with dominant negative Elk-1, wild type, and variant GAL4-Elk-1 fusion proteins confirmed that phosphorylation of Elk-1 at serines 383 and 389 in the C-terminal region of Elk-1 is an important downstream target associated with activation of an SRE by E2.
• OpenBEL Selventa BEL large corpus: ELK1 → MAPK3 (directlyIncreases, ELK1 Activity)
  Evidence: 9130707;8548291;8262053;11145955
• BioCarta mapkinase signaling pathway: ERK1/ERK2 (MAPK3/MAPK1) → ELK-1 (ELK1) (modification, activates)
• KEGG Focal adhesion: MAPK1/MAPK3 → ELK1 (protein-protein, phosphorylation)
• KEGG Insulin signaling pathway: MAPK1/MAPK3 → ELK1 (protein-protein, activation)
• KEGG GnRH signaling pathway: MAPK1/MAPK3 → ELK1 (protein-protein, activation)
• KEGG MAPK signaling pathway: MAPK1/MAPK3 → ELK1 (protein-protein, phosphorylation)
• KEGG Prion diseases: MAPK1/MAPK3 → ELK1 (protein-protein, activation)
• KEGG Leishmaniasis: MAPK1/MAPK3 → ELK1 (protein-protein, activation)
• KEGG Endometrial cancer: MAPK1/MAPK3 → ELK1 (protein-protein, activation)
• KEGG ErbB signaling pathway: MAPK1/MAPK3 → ELK1 (protein-protein, activation)
• NCI Pathway Database Ras signaling in the CD4+ TCR pathway: ELK1 (ELK1) → Erk1-2-active (MAPK3/MAPK1) (modification, collaborate)
  Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
  Evidence: assay, physical interaction
• NCI Pathway Database Ras signaling in the CD4+ TCR pathway: ELK1 (ELK1) → ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1) (modification, collaborate)
  Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
  Evidence: assay, physical interaction
• NCI Pathway Database Ras signaling in the CD4+ TCR pathway: Erk1-2-active (MAPK3/MAPK1) → ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1) (modification, collaborate)
  Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
  Evidence: assay, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: ELK1 (ELK1) → Erk1-2-active (MAPK3/MAPK1) (modification, collaborate)
  Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
  Evidence: assay, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: ELK1 (ELK1) → ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1) (modification, collaborate)
  Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
  Evidence: assay, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: Erk1-2-active (MAPK3/MAPK1) → ERK1-2/ELK1 complex (MAPK3_MAPK1-ELK1) (modification, collaborate)
  Gille et al., EMBO J 1995*, Rao et al., Oncogene 1994*
  Evidence: assay, physical interaction
• Reactome Reaction: MAPK3 → ELK1 (reaction)
• WikiPathways MAPK Cascade: MAPK3/MAPK1 → MBP/MAP2/ELK1 (activation)
• WikiPathways PDGF Pathway: MAPK1/MAPK3 → ELK1 (mim-stimulation)
• WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling: MAPK3 → ELK1 (mim-necessary-stimulation) Barry et al., J Biol Chem 2001*, Yung et al., J Biol Chem 2001*, Suzaki et al., J Biol Chem 2002*, Tanimura et al., J Biol Chem 2002*, Sananbenesi et al., Mol Cell Neurosci 2002*
• WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling: MAPK3 → ELK1 (mim-necessary-stimulation) Barry et al., J Biol Chem 2001*, Yung et al., J Biol Chem 2001*, Suzaki et al., J Biol Chem 2002*, Tanimura et al., J Biol Chem 2002*, Sananbenesi et al., Mol Cell Neurosci 2002*
• WikiPathways Signaling of Hepatocyte Growth Factor Receptor: MAPK1/MAPK3 → ELK1 (activation)
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): MAPK3/MAPK1 → ELK1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: MAPK3 — ELK1 (experimental interaction detection) Janknecht et al., EMBO J 1997*
• IRef Bind_translation Interaction: MAPK3 — ELK1 (experimental interaction detection) Stein et al., J Biol Chem 1997*
• IRef Bind_translation Interaction: MAPK3 — ELK1 (experimental interaction detection) Arbet-Engels et al., FEBS Lett 1999*
• IRef Bind_translation Interaction: MAPK3 — ELK1 (experimental interaction detection) Fukunaga et al., EMBO J 1997
• IRef Bind_translation Interaction: MAPK3 — ELK1 (experimental interaction detection) Zhu et al., Oncogene 2005*
• IRef Bind_translation Interaction: MAPK3 — ELK1 (experimental interaction detection) Janknecht et al., J Biol Chem 1997*
• IRef Biogrid Interaction: MAPK3 — ELK1 (physical association, affinity chromatography technology) Tapinos et al., Proc Natl Acad Sci U S A 2005*
• IRef Biogrid Interaction: MAPK3 — ELK1 (direct interaction, enzymatic study) Coxon et al., Cell Signal 2003*
• IRef Biogrid Interaction: MAPK3 — ELK1 (physical association, affinity chromatography technology) Zhu et al., Oncogene 2005*
• IRef Biogrid Interaction: MAPK3 — ELK1 (direct interaction, enzymatic study) Han et al., Mol Endocrinol 2010*
• IRef Hprd Interaction: MAPK3 — ELK1 (in vivo) Tohgo et al., J Biol Chem 2003, Eliopoulos et al., J Biol Chem 2006, Rao et al., Oncogene 1994*
• IRef Hprd Interaction: MAPK3 — ELK1 (in vitro) Tohgo et al., J Biol Chem 2003, Eliopoulos et al., J Biol Chem 2006, Rao et al., Oncogene 1994*
• IRef Innatedb Interaction: MAPK3 — ELK1 (unknown, -) Tapinos et al., Proc Natl Acad Sci U S A 2005*
• IRef Intact Interaction: MAPK3 — ELK1 (phosphorylation reaction, protein kinase assay) Eliopoulos et al., J Biol Chem 2006
• IRef Ophid Interaction: MAPK3 — ELK1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Majka et al., Eur J Haematol 2000 (Leukemia-Lymphoma, Adult T-Cell) : Activation of MAPK further led to the phosphorylation of the nuclear transcription factor ELK-1
Duan et al., J Biol Chem 2001 : Estrogen receptor mediated activation of the serum response element in MCF-7 cells through MAPK dependent phosphorylation of Elk-1
Chung et al., FASEB J 2001 : This inhibition of Erk1/2 activity is Elk-1 concentration dependent and ATP concentration independent, which suggests that EGCG and TFdiG interfere with the binding of the protein substrate to the kinase
Woo et al., J Clin Endocrinol Metab 2001 : In summary, our studies demonstrate, for the first time, that melatonin can regulate progesterone production, LH receptor, GnRH, and GnRH receptor gene expression through melatonin receptors in human granulosa-luteal cells, which may be mediated via the MAPK pathway and activation of Elk-1
Stevens et al., Science 2002 (MAP Kinase Signaling System) : Knock-out of Sur2 prevents activation by E1A-CR3 and the mitogen activated protein kinase regulated ETS transcription factor Elk-1 , but not by multiple other transcription factors
Bea et al., Circ Res 2003 (MAP Kinase Signaling System) : Furthermore, C pneumoniae stimulated phosphorylation of ERK1/2 and Elk-1 and pharmacological inhibition of mitogen activated protein kinase activity reduced the expression of TF and Egr-1
Chen et al., J Cell Biochem 2004 : Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen activated protein kinase dependent phosphorylation of ELK-1
Vlotides et al., Mol Endocrinol 2006 (Pituitary Neoplasms) : EGF induced EGFR and ERK1/2 phosphorylation was followed by rapid MAPK kinase/ERK kinase dependent activation of Elk-1 and c-Fos
Muddasani et al., J Biol Chem 2007 : Taken together, our results suggest that elevated expression of MMP-13 occurs through Elk-1 activation of both MAPK and NFkappaB signaling pathways, thus revealing a two pronged biological mechanism by which bFGF controls the production of catabolic enzymes that are associated with excessive degradation of the cartilage matrix in degenerative joint diseases such as osteoarthritis
Wang et al., Neurotox Res 2010 : Here, we reported that oxLDL induced MMP-9 expression via a PKC-delta/p42/p44 MAPK dependent Elk-1 activation in rat brain astrocyte ( RBA ) -1 cells, revealed by gelatin zymography, RT-PCR, and Western blotting analyses