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Bruning et al., Proc Natl Acad Sci U S A 2000
:
The reduced Elk-1 activation in KO cells occurs despite normal activation of the mitogen activated protein kinase pathway and normal PDGF- and IGF-1 stimulated Elk-1 phosphorylation
Kim et al., J Biol Chem 1997
:
Whereas PD98059 had no effect on IGF-IR phosphorylation, PD98059 reduced IGF-I mediated ERK tyrosine phosphorylation and ERK phosphorylation of the substrate Elk-1