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AKT1 — EIF4EBP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Takata et al., J Biol Chem 1999
:
Insulin induced phosphorylation of
4E-BP1 was
inhibited by
Akt-AA in Chinese hamster ovary cells ... These data suggest that
Akt , but not PKClambda, is
required for insulin activation of glycogen synthase and for insulin induced phosphorylation of
4E-BP1
Pham et al., Circ Res 2000
:
One mechanism involves
PI3K/PKB dependent phosphorylation of
4E-BP1 , which dissociates from eIF4E, allowing initiation of translation from the 7-methylGTP cap of mRNAs
Aoki et al., Proc Natl Acad Sci U S A 2001
(Cell Transformation, Neoplastic) :
A mutant of
Akt that retains kinase activity but does not
induce phosphorylation of S6K or of
4E-BP1 fails to transform chicken embryo fibroblasts, suggesting a correlation between the oncogenicity of Akt and phosphorylation of S6K and 4E-BP1
Shi et al., J Biol Chem 2002
(MAP Kinase Signaling System...) :
In contrast, IL-6 induced phosphorylation of
4E-BP1 was
inhibited by rapamycin, wortmannin, and dominant negative
AKT but ERK inhibitors had no effect, indicating ERK function was dispensable ... In keeping with these data, a dominant active
AKT mutant was
sufficient to induce
4E-BP1 phosphorylation but could not by itself activate p70 kinase activity ... These results indicate that both ERK and PI3-K/AKT pathways are required for optimal IL-6 induced p70 activity, but
PI3-K/AKT is
sufficient for
4E-BP1 phosphorylation
Vary et al., Mol Cell Biochem 2005
:
Activation of the potential upstream regulators of
4E-BP1 and S6K1 phosphorylation via
PKB and mTOR was also observed
Han et al., Cancer Res 2006
(Carcinoma, Non-Small-Cell Lung...) :
We found that fibronectin stimulated the phosphorylation of
Akt , an upstream inducer of mTOR, and
induced the phosphorylation of p70S6K1 and eukaryotic initiation factor
4E-binding protein 1 (4E-BP1) , two downstream targets of mTOR in NSCLC cells ( H1792 and H1838 ), whereas it inhibited the phosphatase and tensin homologue deleted on chromosome 10, a tumor suppressor protein that antagonizes the phosphatidylinositol 3-kinase/Akt signal
Wollenhaupt et al., Reprod Domest Anim 2007
:
The decrease ( p < 0.05 ) of the abundance of the 80 kDa ERalpha form both by E ( 2 ) and raloxifen indicates that the E ( 2 ) -stimulated
Akt phosphorylation and the
inhibition of
4E-BP1 phosphorylation by raloxifen is an E ( 2 ) ER-transmitted process
Jacobson et al., Br J Cancer 2009
(Mesothelioma) :
An inhibitor of
Akt diminished IGF-I mediated phosphorylation of
4E-BP1 , whereas inhibiting MAPK signalling had no such effect
Kakigi et al., J Physiol Sci 2011
(MAP Kinase Signaling System) :
HS significantly increased the phosphorylation of
Akt/PKB , mTOR, and ribosomal protein S6 at 1 h after exercise ( P < 0.05 ), and the
4E-BP1 phosphorylation level, which had initially decreased with exercise, had
recovered by 1 h after exercise with HS
Gingras et al., Genes Dev 1998
:
Importantly, an activated
Akt induces phosphorylation of
4E-BP1 on the same sites that are phosphorylated upon serum stimulation