Gene interactions and pathways from curated databases and text-mining

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EIF4E — MAPK3

Text-mined interactions from Literome

Takei et al., J Biol Chem 2001 (MAP Kinase Signaling System) : In contrast, insulin failed to activate MAPK and did not induce the phosphorylation of eIF4E
Banerjee et al., J Virol 2002 : Interestingly, there was a transient increase in the amount of phosphorylation of the translation initiation factor 4E ( eIF4E ) in infected cells, and this eIF4E phosphorylation was p38 MAPK dependent ; it is known that phosphorylated eIF4E enhances translation rates of cap containing mRNAs ... MHV utilized this p38 MAPK dependent increase in eIF4E phosphorylation to promote virus-specific protein synthesis and subsequent progeny virus production
Mizutani et al., Biochem Biophys Res Commun 2004 (MAP Kinase Signaling System...) : The p38 MAPK inhibitor, SB203580, inhibited effectively phosphorylation of HSP-27, CREB, and eIF4E in SARS-CoV infected cells
Cowan et al., Eur J Biochem 2004 : Prolonged incubation with MG132 resulted in the increased expression of heat shock protein ( hsp ) 25, alphaB-crystallin and hsp70, with a population of hsp25 associating with the eIF4F complex in a p38 mitogen activated protein kinase dependent manner
Ramesh et al., American journal of physiology. Renal physiology 2007 : Inhibition of p38 MAPK and, to a lesser extent, ERK, reduced cisplatin+endotoxin stimulated TNF-alpha production and phosphorylation of Mnk1 and eIF4E
Jiang et al., Planta Med 2007 (Stomach Neoplasms) : We found that matrine inactivated Erk1/2 , an upstream regulator of 4E-BP1 and eIF4E , and remarkably reduced the phosphorylation level of 4E-BP1 and eIF4E, whereas 4E-BP1 was little influenced by JNK, p38 or Akt/mTOR
Das et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : Inhibition of Erk1/2 by MEK inhibitor or by expression of dominant negative Erk2 blocked eIF4E phosphorylation, resulting in attenuation of TGFß induced protein synthesis and mesangial cell hypertrophy
Jiang et al., FEBS Lett 2013 : MKK3/6 dependent activation of p38MAPK is required for the phosphorylation of eIF4E , thus initiating the translation of ER stress related transcription factor ATF4
Morley et al., J Biol Chem 1997 : However, the rapid enhancement of eIF4E phosphorylation in response to serum was largely prevented by the inhibitor of mitogen activated protein ( MAP ) kinase activation, PD98059