Gene interactions and pathways from curated databases and text-mining

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EIF4E — IGF1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: EIF4E → IGF1 (decreases)
    Evidence: In contrast, a significant eIF-4E dephosphorylation was found.

Text-mined interactions from Literome

Shen et al., J Endocrinol 2005 : Insulin and IGF-I stimulated eukaryotic initiation factor 4E (eIF4E) binding protein ( 4EBP1 ) phosphorylation in a dose dependent manner, and the stimulation was independent of availability of external amino acids
Jacobson et al., Br J Cancer 2009 (Mesothelioma) : Activated 4E-BP1 represses tumourigenesis and IGF-I mediated activation of the eIF4F complex in mesothelioma