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EIF2AK2 — MAPK3
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Goh et al., EMBO J 2000
:
The protein kinase
PKR is
required for p38
MAPK activation and the innate immune response to bacterial endotoxin ... Our findings indicate, for the first time, that
PKR is
required for p38
MAPK signaling and plays a potentially important role in the innate response against bacterial endotoxin
Williams et al., Science's STKE : signal transduction knowledge environment 2001
:
This review will focus on the
role of
PKR in nuclear factor kappa B (NF-kappaB) and
mitogen activated protein kinase ( MAPK ) pathways, because these have been the subjects of a series of publications over the past year that have reported conflicting findings
Gray et al., Toxicological sciences : an official journal of the Society of Toxicology 2008
:
We have previously shown that
PKR mediates DON induced
MAPK phosphorylation in macrophages and monocytes
Eley et al., Am J Physiol Endocrinol Metab 2008
(Muscular Atrophy) :
Activation of p38
MAPK by
PKR provides the link to ROS formation
Russell et al., Exp Cell Res 2009
(Atrophy...) :
Activation of
PKR also
led to activation of
p38MAPK ( mitogen activated protein kinase ), leading to ROS ( reactive oxygen species ) formation, since this was attenuated by the specific p38MAPK inhibitor SB203580
McAllister et al., J Virol 2010
:
Furthermore, protein kinase PKR and mitochondrial adapter IPS-1 were required for maximal C ( ko ) -mediated IFN-beta induction, which correlated with the
PKR mediated enhancement of
mitogen activated protein kinase and NF-kappaB activation
Xu et al., PloS one 2012
(Breast Neoplasms) :
PIC induced activation of p38
MAPK and MK2 was
attenuated by the
PKR inhibitor and the PKR siRNA, but a selective p38 MAPK inhibitor ( SB203580 ) or other MAPK inhibitors did not affect PKR activity, indicating that PKR is upstream of p38 MAPK/MK2