Gene interactions and pathways from curated databases and text-mining

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CASP5 — EIF2AK2

Text-mined interactions from Literome

Saelens et al., J Biol Chem 2001 : Translation inhibition in apoptosis : caspase dependent PKR activation and eIF2-alpha phosphorylation
Page et al., Mol Pharmacol 2002 : PKR in turn can activate caspase-8 independently of death receptor ligation
Suen et al., J Biol Chem 2003 : We report here that inhibition of caspase-3 activity reduces phosphorylation of PKR and to a certain extent, cleavage of PKR and eIF2alpha in neurons exposed to Abeta peptide ... Calcium release from the endoplasmic reticulum and activation of caspase-8 are the upstream signals modulating the caspase-3 mediated activation of PKR by Abeta peptide
Scheuner et al., J Biol Chem 2006 : TNFalpha treatment induced eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase PKR
Lin et al., Anticancer Res 2007 (Nasopharyngeal Neoplasms) : Moreover, for the first time in NPC cells it was demonstrated that the pathway involved in rhein induced apoptosis is caspase dependent, presumably through the endoplasmic reticulum ( ER ) stress pathway, as shown by an increase in the levels of glucose regulated protein 78 (GRP 78), PKR-like ER kinase (PERK) , activating transcription factor 6 ( A TF6 ) and CCAA TIenhancer binding protein homologous protein ( CHOP ) as well as the activation of caspase-3 , -8, -9 and -12
Russell et al., Exp Cell Res 2009 (Atrophy...) : These results suggest that high glucose induces muscle atrophy through the caspase-3/-8 induced activation of PKR , leading to phosphorylation of eIF2alpha and depression of protein synthesis, together with PKR mediated ROS production, through p38MAPK and increased protein degradation
Russell et al., Mol Cell Biochem 2009 : This suggests that LPS induces protein degradation through a signalling cascade involving activation of caspase-3/-8 , activation of PKR and production of ROS through p38MAPK, and that this process is attenuated by HMB
Couturier et al., J Biol Chem 2010 (Alzheimer Disease) : However, PKR gene silencing or treatment with a specific PKR inhibitor significantly prevented the increase in pT ( 451 ) -PKR and pS ( 194 ) -FADD levels in SH-SY5Y nuclei and completely inhibited activities of caspase-3 and -8
Dedoni et al., J Neurochem 2010 (Neuroblastoma) : PKR induction was associated with enhanced PKR activity and chemical inhibition of PKR reduced IFN stimulated caspase activation
Supinski et al., J Appl Physiol 2011 (Muscle Weakness...) : Finally, we investigated if inhibition of PKR ( using either 2-aminopurine or transfection with dominant negative PKR ) blocks caspase-8 activation in cytokine treated C2C12 cells ... Inhibition of PKR with 2-aminopurine prevented endotoxin induced diaphragm caspase-8 activation ( P < 0.01 ) and diaphragm weakness ( P < 0.001 ) ... Inhibition of PKR with either 2-aminopurine or transfection with dominant negative PKR blocked caspase-8 activation in isolated cytokine treated C2C12 cells
Fasano et al., Biochim Biophys Acta 2012 (Colonic Neoplasms) : We suggest that pERK1/2 could be the first upstream target for DHA, and demonstrate that, downstream of GRP78, DHA may exert its proapoptotic role by augmenting the expression of the ER resident factors ERdj5 and inhibiting the phosphorylation of PKR-like ER kinase (PERK) , known to be both physically associated with GRP78, and by activating caspase-4
Hett et al., Nat Chem Biol 2013 (Inflammation) : Further, we show that PKR 's role in ASC assembly and caspase-1 activation induced by several different inflammasome stimuli is independent of PKR 's kinase activity, demonstrating that PKR has a previously uncharacterized role in caspase-1 activation and pyroptosis that is distinct from its reported kinase dependent roles in apoptosis and inflammasome formation in lipopolysaccharide primed cells