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ARF6 — EHMT1
Text-mined interactions from Literome
Paliwal et al., Mol Cell Biol 2006
(Colonic Neoplasms) :
Interaction with
ARF resulted in proteasome dependent
CtBP degradation ... Both
ARF induced CtBP degradation and
CtBP small interfering RNA led to p53 independent apoptosis in colon cancer cells ...
ARF induction of apoptosis was
dependent on its ability to interact with
CtBP , and reversal of ARF induced CtBP depletion by CtBP overexpression abrogated ARF induced apoptosis
Chen et al., EMBO J 2010
:
The p53 activator
ARF inhibits SUV39H1 and
EHMT1 binding to MDM2 and reduces MDM2 associated methyltransferase activity