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Bae et al., Cancer Res 1999
(Carcinoma, Hepatocellular...) :
Egr-1 mediates transcriptional activation of IGF-II gene in response to hypoxia ... Cotransfection of HepG2 cells with an Egr-1 expression vector and an IGF-II P3 promoter-luciferase reporter plasmid showed that the transcription of IGF-II was activated by Egr-1 in a dose dependent manner ... Taken together, these data strongly indicate that hypoxia induced IGF-II expression in HepG2 cells is due to the enhanced activity of Egr-1 on the IGF-II P3 promoter and that the Egr-1 binding site in the IGF-II P3 promoter is essential for the transcriptional regulation of IGF-II under hypoxic conditions
Moorehead et al., J Biol Chem 2003
:
IGF-II induced PTEN promoter activity and protein levels and this involved the immediate early gene egr-1 Youreva et al., Can J Physiol Pharmacol 2013
:
In addition, IGF-1 induced expression of early growth response protein 1 (Egr-1) which plays a pathogenic role in vascular dysfunctions, was also attenuated by curcumin
Lee et al., DNA Cell Biol 1996
:
Conversely, we have shown that the Egr-1 activates transcription of the IGF-II gene through the same response element