Gene interactions and pathways from curated databases and text-mining

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EGLN3 — HIF1A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Marxsen et al., Biochem J 2004 (Adenocarcinoma, Clear Cell...) : In the human osteosarcoma cell line, U2OS, selective suppression of HIF-1alpha expression by RNA interference resulted in a complete loss of hypoxic induction of PHD2 and PHD3
Aprelikova et al., J Cell Biochem 2004 : We further tested the regulation of these genes by HIF-1 and HIF-2 and found that siRNA targeted degradation of HIF-1alpha and HIF-2alpha results in decreased hypoxia induced PHD3 expression
To et al., J Biol Chem 2005 : In this study, we demonstrated that apart from promoting HIF-1alpha proteolysis in normoxia, EGLN1 specifically represses HIF-1alpha transcriptional activity in hypoxia
Ietta et al., Biol Reprod 2006 (Anoxia) : Inhibition of EGLN activity increased HIF1A stability in villous explants and stimulated transforming growth factor beta 3 ( TGFB3 ) expression consistent with promoter analyses showing that HIF1A transactivates TGFB3