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EGLN3 — HIF1A
Pathways - manually collected, often from reviews:
-
KEGG Pathways in cancer:
EGLN1/EGLN2/EGLN3
→
EPAS1/HIF1A
(protein-protein, missing interaction)
-
KEGG Renal cell carcinoma:
EGLN1/EGLN2/EGLN3
→
EPAS1/HIF1A
(protein-protein, activation)
-
Reactome Reaction:
HIF1A
→
EGLN3
(reaction)
Jaakkola et al., Science 2001, Ivan et al., Science 2001, Bruick et al., Science 2001, Ivan et al., Proc Natl Acad Sci U S A 2002*, Metzen et al., J Cell Sci 2003, Hirsilä et al., J Biol Chem 2003*, Berra et al., EMBO J 2003*, Appelhoff et al., J Biol Chem 2004*, Tuckerman et al., FEBS Lett 2004*, Fedulova et al., Protein Expr Purif 2007*, Rantanen et al., Mol Biol Cell 2008*, Tian et al., J Biol Chem 2011*
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
HIF1A
—
EGLN3
(affinity chromatography technology)
Baek et al., Mol Cell 2005*
-
IRef Biogrid Interaction:
HIF1A
—
EGLN3
(physical association, affinity chromatography technology)
Yeh et al., Biochem J 2013*
-
IRef Biogrid Interaction:
HIF1A
—
EGLN3
(direct interaction, pull down)
Baek et al., Mol Cell 2005*
-
IRef Biogrid Interaction:
HIF1A
—
EGLN3
(direct interaction, pull down)
Yoo et al., Oncogene 2008*
-
MIPS CORUM HIF1A-OS9-EGLN3 complex:
HIF1A-OS9-EGLN3 complex complex (EGLN3-HIF1A-OS9)
Baek et al., Mol Cell 2005*
-
IRef Hprd Interaction:
Complex of HIF1A-MTA1-EGLN3-MTA1-HIF1A-EGLN3-EGLN3-MTA1-HIF1A
(in vivo)
Yoo et al., EMBO J 2006
-
IRef Hprd Interaction:
HIF1A
—
EGLN3
(in vitro)
Tuckerman et al., FEBS Lett 2004*, Baek et al., Mol Cell 2005*, Yoo et al., EMBO J 2006
-
IRef Hprd Interaction:
HIF1A
—
EGLN3
(in vivo)
Tuckerman et al., FEBS Lett 2004*, Baek et al., Mol Cell 2005*, Yoo et al., EMBO J 2006
-
IRef Innatedb Interaction:
HIF1A
—
EGLN3
(unknown, -)
Barth et al., Mol Cell Biol 2007*
-
IRef Innatedb Interaction:
HIF1A
—
EGLN3
(unknown, -)
Scholz et al., Proc Natl Acad Sci U S A 2013
-
IRef Intact Interaction:
Complex of HIF1A-VHL-EGLN3-EGLN3-HIF1A-VHL
(physical association, two hybrid)
Bex et al., Nucleic Acids Res 2007
-
IRef Intact Interaction:
HIF1A
—
EGLN3
(physical association, anti bait coimmunoprecipitation)
Yoo et al., EMBO J 2006
-
IRef Intact Interaction:
HIF1A
—
EGLN3
(hydroxylation reaction, experimental interaction detection)
Tuckerman et al., FEBS Lett 2004*
-
IRef Intact Interaction:
Complex of OS9-HIF1A-EGLN3-OS9-HIF1A-EGLN3-OS9-EGLN3-HIF1A
(association, pull down)
Baek et al., Mol Cell 2005*
Text-mined interactions from Literome
Marxsen et al., Biochem J 2004
(Adenocarcinoma, Clear Cell...) :
In the human osteosarcoma cell line, U2OS, selective suppression of
HIF-1alpha expression by RNA interference
resulted in a complete loss of hypoxic induction of PHD2 and
PHD3
Aprelikova et al., J Cell Biochem 2004
:
We further tested the regulation of these genes by HIF-1 and HIF-2 and found that siRNA targeted degradation of
HIF-1alpha and HIF-2alpha
results in decreased hypoxia induced
PHD3 expression
To et al., J Biol Chem 2005
:
In this study, we demonstrated that apart from promoting HIF-1alpha proteolysis in normoxia,
EGLN1 specifically
represses HIF-1alpha transcriptional activity in hypoxia
Ietta et al., Biol Reprod 2006
(Anoxia) :
Inhibition of
EGLN activity
increased HIF1A stability in villous explants and stimulated transforming growth factor beta 3 ( TGFB3 ) expression consistent with promoter analyses showing that HIF1A transactivates TGFB3