Gene interactions and pathways from curated databases and text-mining

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EGFR — IGF1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: EGFR → IGF1 (increases, IGF1 Activity)
    Evidence: the EGF receptor can also be activated indirectly by IGF1
  • OpenBEL Selventa BEL large corpus: EGFR → IGF1 (increases, IGF1 Activity)
    Evidence: transactivation of the EGF receptor by IGF1 is blocked by ZD1839
  • OpenBEL Selventa BEL large corpus: EGFR → IGF1 (increases, IGF1 Activity) DiCamillo et al., J Biol Chem 2002*
    Evidence: Transient tyrosine phosphorylation of EGFR leading to ERK activation has been shown to be induced by a wide variety of extracellular stimuli, which do not belong to the family of canonical EGFR ligands. This.. transactivation of EGFR can be initiated by ... hepatopoietin, insulin-like growth factor 1, and PDGF (45?48).
  • KEGG Focal adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC → EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB (protein-protein, activation)
  • KEGG Prostate cancer: EGF/IGF1/INS/PDGFA/PDGFB/PDGFC/PDGFD/TGFA → EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB (protein-protein, activation)
  • KEGG Melanoma: EGF/FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD → EGFR/FGFR1/IGF1R/MET/PDGFRA/PDGFRB (protein-protein, activation)
  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  • WikiPathways Focal Adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC → BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 (activation)

Text-mined interactions from Literome

Molina-Muñoz et al., Mol Endocrinol 2006 : Insulin-like growth factor-I induces alpha ( 1B ) -adrenergic receptor phosphorylation through G beta gamma and epidermal growth factor receptor transactivation
Huether et al., World J Gastroenterol 2006 (Carcinoma, Hepatocellular...) : Erlotinib induced alterations in gene expression were evaluated using cDNA array technology ; changes in protein expression and/or protein activation due to erlotinib treatment as well as IGF-1 induced EGFR transactivation were investigated using Western blotting
Zhou et al., FEBS Lett 2006 (Prostatic Neoplasms) : Here, we demonstrated in prostate cancer DU145 cells that IGF-1 induced EGFR transactivation, leading to ERK activation ... Antioxidants and catalase inhibited IGF-1 stimulated EGFR phosphorylation, indicating that H ( 2 ) O ( 2 ) is required for EGFR activation
Fang et al., Carcinogenesis 2007 (Prostatic Neoplasms) : Luteolin also inhibited the IGF-1 induced activation of EGFR and MAPK/ERK signaling
Meng et al., Free Radic Biol Med 2007 : Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species ... We showed that IGF-I induced phosphorylation of EGFR and ERK1/2 in VSMCs. AG1478, an EGFR inhibitor, inhibited IGF-I induced phoshorylation of EGFR and ERK1/2 ... Antioxidants inhibited IGF-I induced ROS generation and activation of EGFR , ERK, and Src ... Src kinase inhibitor PP1 and Src siRNA blocked IGF-I induced activation of EGFR and ERK1/2 ... Inhibition of IGF-I stimulated EGFR activation inhibited IGF-I induced VSMC proliferation ... These results suggest that ( 1 ) IGF-I induces EGFR activation through production of ROS and ROS mediated Src activation in VSMCs, and ( 2 ) EGFR transactivation is required for IGF-I induced VSMC proliferation
Morgillo et al., Clin Cancer Res 2007 (Carcinoma, Non-Small-Cell Lung...) : Treatment with gefitinib, but not cetuximab, induced EGFR : IGF-IR heterodimerization and activation of IGF-IR and its downstream signaling mediators, resulting in increased survivin expression in NSCLC cell lines with high levels of IGF-IR expression
Song et al., Endocrinology 2007 (Breast Neoplasms) : Using MCF-7 breast cancer cells, we for the first time demonstrated that a sequential activation of IGF-IR, MMP, and EGFR existed in E2 and IGF-I actions, which was supported by evidence that the selective inhibitors of IGF-IR and MMP or knockdown of IGF-IR all inhibited E2- or IGF-I induced EGFR phosphorylation ... Using MCF-7 breast cancer cells, we for the first time demonstrated that a sequential activation of IGF-IR, MMP, and EGFR existed in E2 and IGF-I actions, which was supported by evidence that the selective inhibitors of IGF-IR and MMP or knockdown of IGF-IR all inhibited E2- or IGF-I induced EGFR phosphorylation
Barnes et al., Clin Cancer Res 2007 (Head and Neck Neoplasms) : Stimulation of head and neck cancer cells with either IGF or EGF resulted in IGF-IR and EGFR heterodimerization, but only IGF caused activating phosphorylation of both receptors
Li et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : In addition, the enhanced phosphorylation of EGF-R in VSMC from SHR compared with WKY was also attenuated by inhibitors of AT(1), ET ( A ), ET ( B ), and EGF-R but not by inhibitors of platelet derived growth factor receptor or insulin-like growth factor receptor
Shaw et al., Br J Cancer 2011 (Adenoma...) : We show here that, in murine intestinal adenomas acutely exposed to a small molecular inhibitor of EGFR ( gefitinib ), there is concurrent suppression of EGFR downstream signalling and induction of IGF signalling
Chand et al., J Immunol 2012 (Chronic Disease...) : Blocking epidermal growth factor receptor or IGF-1R activation also suppressed IC-IGF-1 and abolished the Bcl-2 induction
Lin et al., J Lab Clin Med 1995 (Acute Kidney Injury...) : Insulin-like growth factor-1 enhances epidermal growth factor receptor activation and renal tubular cell regeneration in postischemic acute renal failure ... Furthermore, they suggest that EGF-R activation is involved in tubular regeneration and that IGF-1 may enhance EGF-R activation by increasing EGF-R expression
Vardy et al., J Cell Physiol 1995 : Induction of autocrine epidermal growth factor receptor ligands in human keratinocytes by insulin/insulin-like growth factor-1