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EGF — HIF1A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: HIF1A → EGF (increases)
  Evidence: In addition to activation by hypoxia, the HIF system is also induced or amplified by a wide range of growth-promoting stimuli and oncogenic pathways such as the insulin, insulin-like growth factor-1, epidermal growth factor and mutant Ras and Src kinase pathways.

Text-mined interactions from Literome

Lim et al., Oncogene 2004 (Neoplasms) : We here found that the Ras oncogene regulates HIF-1alpha ( 785 ) expression via the Raf/MEK/ERK pathway, and that both phorbol ester and epidermal growth factor also induced HIF-1alpha ( 785 ) via the same pathway
Schultz et al., Am J Physiol Heart Circ Physiol 2006 (Anoxia) : Moderate hypoxia elicited increased cellular HIF-1alpha levels, shown by Western blot analysis, and also enhanced PDGF-, FGF-2-, and EGF induced expression of HIF-1alpha
Liu et al., Free Radic Biol Med 2006 (Neovascularization, Pathologic) : This study demonstrates a novel mechanism of EGF induced VEGF and HIF-1alpha expression through production of H2O2 and activation of AKT and p70S6K1 in human ovarian cancer cells
Tanaka et al., Cancer Res 2006 (Anoxia...) : Treating the HCC cells with IGF-II or epidermal growth factor (EGF) up-regulated both phospho-Akt and HIF-1alpha, whereas inhibition of IGF-II or EGF signaling down-regulated them both, suggesting that IGF-II and EGF can, at least in part, mediate the activation of Akt and HIF-1alpha