Frederickson et al., Mol Cell Biol 1992
:
In contrast, epidermal growth factor , a factor which elicits a weak mitogenic response in PC12 cells, did not significantly enhance eIF-4E phosphorylation
Diggle et al., Biochem J 1996
:
This study compares the effects of insulin and epidermal growth factor (EGF) on the phosphorylation of 4E-BP1 in fat-cells ( followed by gel-shift assays and incorporation of 32P ) and on its association with eIF-4E Kleijn et al., J Cell Biochem 1995
(Teratocarcinoma) :
By using P19 cells overexpressing the EGF receptor, we show that the signal transduction pathway that leads to phosphorylation of eIF-4E is present in P19 cells ; the EGF induced change in phosphorylation of eIF-4E in these cells is likely to be regulated by a change in eIF-4E phosphatase activity